Table 2: Metabolic and hemodynamic responses at rest, during and after exercise in T2D patients and control subjects during placebo and CoQ10 conditions.


Group

 T2D (n = 7)

 Control (n = 7)

P

P

P

Trial

 Placebo

 CoQ10

 Placebo

 CoQ10

Group

Tx

Inter

Resting

 

 

 

 

 

 

 

PCr (mM)

39.12 ± 1.98

38.93 ± 3.66

41.09 ± 2.13

39.82 ± 1.76

0.459

0.637

0.358

Pi (mM)

5.84 ± 1.07

4.99 ± 1.75

4.78 ± 1.06

4.61 ± 0.95

0.237

0.518

0.695

ipH

7.02 ± 0.02

7.00 ± 0.02

7.01 ± 0.04

7.02 ± 0.01

0.329

0.319

0.218

Exercise

 

 

 

 

 

 

 

SSI Ex. Duration (s)

312.8 ± 117.6

321.7 ± 135.5

408.9 ± 103.5

424.6 ± 88.3

0.030

0.720

1.00

NIRS

 

 

 

 

 

 

 

T50

70.93 ± 52.13

69.10 ± 33.72

31.83 ± 8.36

32.43 ± 10.02

0.004

0.960

0.920

BFindex (%/s)

5.33 ± 2.88

3.99 ± 2.23

9.74 ± 2.92

9.22 ± 2.42

0.010

0.469

0.736

MRS

 

 

 

 

 

 

 

End PCr (mM)

45.58 ± 17.24

42.13 ± 4.68

49.4 ± 17.60

51.76 ± 14.57

0.562

0.632

0.980

PCrre (mM·kg·min-1)

22.31 ± 13.35

23.20 ± 11.39

49.37 ± 36.61

43.74 ± 33.28

0.034

0.905

0.960

Tc (s)

67.21 ± 69.51

53.61 ± 22.55

35.59 ± 23.65

32.54 ± 15.18

0.014

0.802

0.770

pH End ex. (12-s)

6.979 ± 0.074

6.96 ± 0.036

7.002 ± 0.036

7.004 ±0.049

0.094

0.663

0.586

pH 1 min post ex. (12-s)

6.886 ± 0.064

6.915 ± 0.063

6.972 ± 0.038

6.988 ± 0.059

0.001

0.311

0.793

Note: PCr: Phosphocreatine; Pi: Inorganic phosphate; ipH: intracellular pH; T50NIR: Time to 50% of Hemoglobin/Myoglobin-reoxygenation from cessation of exercise; BFindex: Blood flow index; End PCr: End exercise PCr; PCrre: Phosphocreatine resynthesis rate; Tc: Time constant; 12-s: 12-s all out exercise; SSI: steady state incremental exercise. Data are expressed in mean ± SD.