Table 1: Demographic and clinical characteristics of Type 1 vs. Type 2 patients at admission to INDEN's pediatric clinic between 2000 and 2016.†
|
Total Population N (%) or Mean ± SD (n = 874) |
Type 1 N (%) or Mean ± SD (n = 696) |
Type 2 N (%) or Mean ± SD (n = 178) |
P-value |
Age (years) |
10.95 ± 4.14 |
10.43 ± 4.24 |
13.27 ± 2.67 |
< 0.0001 |
Sex (% Female) |
489 (56.08) |
373 (53.67) |
116 (65.54) |
0.0045 |
Resides within Santo Domingo Province |
483 (56.82) |
367 (54.29) |
116 (66.67) |
0.0033 |
Family history |
|
|
|
|
First degree (parent, sibling) |
185 (21.29) |
96 (13.89) |
89 (50.00) |
< 0.0001 |
Second degree (grandparent) |
404 (46.49) |
299 (43.27) |
105 (58.99) |
0.0002 |
Overweight or obese (WHO categorization) |
317 (46.08) |
191 (36.94) |
126 (73.68) |
< 0.0001 |
Duration of diabetes (years) |
3.15 ± 3.26 |
3.43 ± 3.45 |
2.07 ± 2.04 |
0.0003 |
Average Annual Visit Frequency |
3.17 ± 1.36 |
3.14 ± 1.38 |
3.30 ± 1.23 |
0.0051 |
Hospitalized |
331 (38.44) |
292 (42.63) |
39 (21.16) |
< 0.0001 |
Hypoglycemic episodes (as a patient) |
393 (45.02) |
333 (47.91) |
60 (33.71) |
< 0.0001 |
Ketoacidosis episodes (as a patient) |
98 (11.40) |
90 (13.14) |
8 (4.57) |
0.0015 |
Two or more episodes of hospitalization, hypoglycemia, or ketoacidosis |
46 (5.65) |
42 (6.53) |
4 (2.34) |
0.0348 |
Lost to follow up |
560 (64.15) |
441 (63.45) |
119 (66.85) |
0.4066 |
Self-monitoring |
324 (37.72) |
273 (39.68) |
51 (29.82) |
< 0.0221 |
HbA1c % (mmol/mol) |
9.86 ± 3.14 |
9.94 ± 3.17 |
9.57 ± 3.02 |
0.3988 |
Cholesterol (mg/dL) |
167.99 ± 43.87 |
169.65 ± 44.00 |
161.39 ± 42.94 |
0.0839 |
Triglycerides (mg/dL) |
90.96 ± 75.21 |
85.72 ± 71.44 |
111.74 ± 85.90 |
0.0002 |
HDL (mg/dL) |
50.08 ± 16.60 |
52.10 ± 16.72 |
43.03 ± 14.13 |
< 0.0001 |
LDL (mg/dL) |
101.69 ± 38.84 |
103.35 ± 38.25 |
95.83 ± 40.61 |
0.1190 |
c-peptide (ng/mL) |
0.90 ± 1.04 |
0.64 ± 0.88 |
1.66 ± 1.10 |
< 0.0001 |
Anti-GAD (un/mL) |
20.42 ± 32.01 |
21.50 ± 32.58 |
1 |
0.2613 |
Anti-ICA |
31.88 ± 31.95 |
35.71 ± 32.46 |
5 |
0.2575 |
Comorbidities‡ |
|
|
|
|
Hypertension |
2 (0.23) |
2 (0.29) |
0 |
N/a |
Asthma |
36 (4.12) |
31 (4.45) |
5 (2.81) |
N/a |
Thyroid disease |
50 (5.72) |
41 (5.89) |
9 (5.06) |
N/a |
Polycystic ovary |
7 (0.80) |
4 (0.57) |
3 (1.69) |
N/a |
Gastroparesis |
2 (0.23) |
2 (0.29) |
0 |
N/a |
BMI: Body Mass Index; HbA1c: Hemoglobin A1c; HDL: High-Density Lipoprotein; LDL: Low-Density Lipoprotein; Anti-GAD: Anti-Glutamic Acid Decarboxylase Antibody; Anti-ICA: Antibodies Against Islet Cells; †Categories may not sum to total due to missing values; ‡One patient may have more than one comorbidity.