Subgroup analysis of percentage change in area of retinal microhaemorrhages per area of retina in Treatment group between baseline and week 36.

Table 5: Subgroup analysis of percentage change in area of retinal microhaemorrhages per area of retina in Treatment group between baseline and week 36.

Grade of Non-proliferative Diabetic Retinopathy	n	Retinal microhaemorrhages change from Baseline to Week 36 in Treatment Group
Grade of Non-proliferative Diabetic Retinopathy	n	Median percentage change (%)	r	P-value
Mild	12	- 25.8	0.679	0.019^*
Moderate	9	- 59.8	0.770	0.021^*

*Effect size significant at p < 0.05; n: number of eyes; r: effect size from Wilcoxon signed-rank test within subjects (small effect: r > 0.1, medium effect: r > 0.3, large effect: r > 0.5).