Subgroup analysis of percentage change in area of diabetic macular edema per area of retina in Treatment group between baseline and week 36.

Table 7: Subgroup analysis of percentage change in area of diabetic macular edema per area of retina in Treatment group between baseline and week 36.

Grade of Non-proliferative Diabetic Retinopathy	n	Diabetic macular edema change from Baseline to Week 36 in Treatment Group
Grade of Non-proliferative Diabetic Retinopathy	n	Median percentage change (%)	r	P-value
Mild	6	- 55.1	0.727	0.075
Moderate	7	- 33.8	0.894	0.018^*

*Effect size significant at p < 0.05; n: number of eyes; r: effect size from Wilcoxon signed-rank test within subjects (small effect: r > 0.1, medium effect: r > 0.3, large effect: r > 0.5).