Half-lives (t1/2) of triazene derivatives (18a-18f) in PBS buffer, 80% human plasma and in the presence of tyrosinase (300 U/mL) at 37ºC.

Table 2: Half-lives (t_1/2) of triazene derivatives (18a-18f) in PBS buffer, 80% human plasma and in the presence of tyrosinase (300 U/mL) at 37ºC.

Compound	X	t_1/2
Compound	X	7.4 buffer (h)	80% human lasma (h)	Tyrosinase (min)
18a	COMe	56.6 ± 1.0	1.41 ± 0.13	19.9 ± 1.2
18b	CO₂Et	70.3 ± 0.8	5.32 ± 0.08	18.0 ± 1.2
18c	CN	42.7 ± 0.5	1.23 ± 0.17	15.6 ± 1.8
18d	Br	^a	6.80± 0.01	8.9 ± 0.10
18e	CONH₂	40.6 ± 0.6	5.19 ± 0.08	17.4 ± 0.42
18f	CO₂Me	75.1± 1.7	2.80 ± 0.26	18.3 ± 0.56

Substrate concentration 10^-5 M.

^aStable for 15 days.