Table 1: Clinical findings, therapy and follow-up in 10 patients with folliculotropic mycosis fungoides.

Case

Age at diagnosis

(years)

Duration  skin lesions before diagnosis (years)

Sex

Clinical presentation

Location

Stage at diagnosis

Progression

Initial treatment

CR to initial treatment

Other therapies

Outcome

1

45

2

M

Infiltrated plaques, follicular prominence, alopecia, nodules, later tumors,

Trunk, face, genital, extremities

IA-B

Yes, tumor

PUVA

NA

Local RT, interstitial RT, electron beam RT, BCNU, topical steroids

ASD

2

70

2

F

Patches, infiltrated plaques, nodule, follicular prominence

Arms, face, buttocks

IA-B

No

BCNU

No

Local RT, topical steroids, PUVA

ASD

3

45

13

M

Patches, Infiltrated plaques, follicular prominence, tumors, comedo-like lesions, alopecia

Face, scalp, trunk, extremities, buttocks and genital

IVA (T3N3M0)

Yes, erythrodermic MF

CHVmP-BV

Yes , with recurrence 1 year later

PUVA, total skin RT, local RT, MOPP, chlorambucil-prednisone, acitretin, prednisone

DOL

4

45

19

M

Infiltrated plaques, alopecia, follicular papules

Legs, trunk, arms

IA-B

No

BCNU

Yes

PUVA, IFNalpha

NED

5

38

11

M

Infiltrated plaques, patches, follicular prominence, later nodule and tumors

Face and neck, extremities, trunk

IA-B

Yes, tumor, nodal involvement

PUVA and BCNU

No

Topical steroids, IFN alpha, isotretinoin, Total skin RT, chlorambucil-prednisone, bexarotene

APD

6

34

11

M

Patches, follicular papules, pustular, nodule, comedo-like lesions, alopecia

Face and neck

IA

No

PUVA

No

Topical steroids, isotretinoin, BCNU, local RT, topic tacrolimus

ASD

7

18

1

F

Infiltrated plaques, later alopecia and tumors

Trunk, then generalized

IA-B

Yes, tumor, nodal involvement

Isotretinoin

No

PUVA, BCNU, IFN alpha, topical steroids, chlorambucil-prednisone, bexarotene, promace-MOPP, Steroids, RT, study medication

DOL

8

39

13

M

Patches, infiltrated plaques, hypopigmentation, alopecia, comedo-like lesions

Legs, then generalized

IA-B

No

PUVA

NA

BCNU

ASD

9

63

4

M

Patches, infiltrated plaques, follicular papules, alopecia

Trunk, extremities, buttocks

IA-B

No

PUVA

No

Topical steroids, BCNU

ASD

10

71

12

M

Patches, infiltrated plaques, follicular prominence, nodule, alopecia, comedo-like lesions

Trunk, extremities, genital, face, scalp

IA-B

Yes, nodal involvement and lung involvement

PUVA

No

IFN alpha, topical steroids, BCNU, CHOP

DOL

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

M = Male, F = Female; NA = Not available; CR = Complete remission; RT = Radiotherapy; PUVA = Psoralen + UVA; BCNU = Chlormustine or bis-chloronitrosourea; CHVmP-BV = Cyclophosphamide, doxorubicin, teniposide and prednisone with bleomycin and vincristine; CHOP = Cyclophosphamide, hydroxydaunorubicin (doxorubicin), Oncovin (vincristine), and prednisone; MOPP = Mustargen, Oncovin (vincristine), Procarbazine, Prednisone; ASD = Alive with stable disease; NED = No evidence of disease; APD = Alive with progressive disease; DOL = Died of lymphoma progression