Table 1: Clinical findings, therapy and follow-up in 10
patients with folliculotropic mycosis fungoides.
Case |
Age at diagnosis (years) |
Duration skin lesions before diagnosis (years) |
Sex |
Clinical presentation |
Location |
Stage at diagnosis |
Progression |
Initial treatment |
CR to initial treatment |
Other therapies |
Outcome |
1 |
45 |
2 |
M |
Infiltrated
plaques, follicular prominence, alopecia, nodules, later tumors, |
Trunk,
face, genital, extremities |
IA-B |
Yes,
tumor |
PUVA |
NA |
Local
RT, interstitial RT, electron beam RT, BCNU, topical steroids |
ASD |
2 |
70 |
2 |
F |
Patches,
infiltrated plaques, nodule, follicular prominence |
Arms,
face, buttocks |
IA-B |
No |
BCNU |
No |
Local
RT, topical steroids, PUVA |
ASD |
3 |
45 |
13 |
M |
Patches,
Infiltrated plaques, follicular prominence, tumors, comedo-like
lesions, alopecia |
Face,
scalp, trunk, extremities, buttocks and genital |
IVA
(T3N3M0) |
Yes,
erythrodermic MF |
CHVmP-BV |
Yes
, with recurrence 1 year later |
PUVA,
total skin RT, local RT, MOPP, chlorambucil-prednisone,
acitretin, prednisone |
DOL |
4 |
45 |
19 |
M |
Infiltrated
plaques, alopecia, follicular papules |
Legs,
trunk, arms |
IA-B |
No |
BCNU |
Yes |
PUVA,
IFNalpha |
NED |
5 |
38 |
11 |
M |
Infiltrated
plaques, patches, follicular prominence, later nodule and tumors |
Face
and neck, extremities, trunk |
IA-B |
Yes,
tumor, nodal involvement |
PUVA
and BCNU |
No |
Topical
steroids, IFN alpha, isotretinoin, Total skin RT, chlorambucil-prednisone, bexarotene |
APD |
6 |
34 |
11 |
M |
Patches,
follicular papules, pustular, nodule, comedo-like
lesions, alopecia |
Face
and neck |
IA |
No |
PUVA |
No |
Topical
steroids, isotretinoin, BCNU, local RT, topic tacrolimus |
ASD |
7 |
18 |
1 |
F |
Infiltrated
plaques, later alopecia and tumors |
Trunk,
then generalized |
IA-B |
Yes,
tumor, nodal involvement |
Isotretinoin |
No |
PUVA,
BCNU, IFN alpha, topical steroids, chlorambucil-prednisone,
bexarotene, promace-MOPP,
Steroids, RT, study medication |
DOL |
8 |
39 |
13 |
M |
Patches,
infiltrated plaques, hypopigmentation, alopecia, comedo-like
lesions |
Legs,
then generalized |
IA-B |
No |
PUVA |
NA |
BCNU |
ASD |
9 |
63 |
4 |
M |
Patches,
infiltrated plaques, follicular papules, alopecia |
Trunk,
extremities, buttocks |
IA-B |
No |
PUVA |
No |
Topical
steroids, BCNU |
ASD |
10 |
71 |
12 |
M |
Patches,
infiltrated plaques, follicular prominence, nodule, alopecia, comedo-like lesions |
Trunk,
extremities, genital, face, scalp |
IA-B |
Yes,
nodal involvement and lung involvement |
PUVA |
No |
IFN
alpha, topical steroids, BCNU, CHOP |
DOL |
M = Male, F =
Female; NA = Not available; CR = Complete remission; RT = Radiotherapy; PUVA = Psoralen + UVA; BCNU = Chlormustine
or bis-chloronitrosourea; CHVmP-BV
= Cyclophosphamide, doxorubicin, teniposide and
prednisone with bleomycin and vincristine; CHOP = Cyclophosphamide,
hydroxydaunorubicin (doxorubicin), Oncovin (vincristine), and prednisone; MOPP = Mustargen, Oncovin
(vincristine), Procarbazine, Prednisone; ASD = Alive with stable
disease; NED = No evidence of disease; APD = Alive with progressive disease; DOL
= Died of lymphoma progression