Table 3: Lab results and clinical assessments [Revised PsAACTH13 DATA 5-4-15, table 2].

 

Subject

Week

CDAI

[PsAACTH13 CDAI DATA (2)]

Tender joint count

Swollen joint count

VAS pain measurement

[Revised PsAACTH13 DATA 5-4-15, table 1]

Cortisol (Pre/Post Acthar Gelb), mcg/dL

CRP, mg/dLa

ESR, mm/hra

2

0

47

18

12

8

18.6/41.7

-

12

12

27

15

7

5

11.5/46.7

1.39

19

24

11

5

3

2

12.5/41.9

0.66

1

5

0

42

20

13

8

8.6/33.3

-

24

12

2

0

1

0

12.4/33.8

0.88

23

24

6

3

2

2

13.8/32.7

0.45

21

6

0

50

24

16

8

6.4/28.4

< 0.10

6

12

2

0

1

0

5.2/23.7

< 0.10

4

24

5

1

2

0

3.7/28.2

< 0.10

3

9

0

47

20

17

10

15.7/18.1

0.21

10

12

4

2

1

0

7.3/28.3

1.91

14

24

5

2

1

0

18.4/29.7

0.39

10

10

0

44

18

18

7

12.7/25.5

0.18

18

12

0

0

0

0

14.2/33.0

0.41

15

24

0

0

0

0

11.2/35.4

0.41

15

12

0

48

19

10

8

7.5/25.5

< 0.32

5

12

4

3

0

3

7.6/27.2

4.81

20

24

-

-

-

-

-

-

-

13

0

33

12

8

9

15.9/31.6

4.20

92

12

0

0

0

0

7.2/40.0

0.16

10

24

0

0

0

0

9.4/2.7

0.23

9

14

0

41

19

10

7

2.6/11.8

< 0.10

3

12

2

1

0

1

7.1/26.1

< 0.10

0

24

3

0

0

1

18.5/28.7

1.31

15

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

aInitial ESR and CRP were conducted at screening, not Week 0.

bCortisol levels were obtained prior to and 1 hour after administration of Acthar Gel.

 

CDAI: Clinical Disease Activity Index; CRP: C-Reactive Protein; ESR: Erythrocyte Sedimentation Rate; VAS: Visual Analog Scale.