Table 1: Clinical description of dermatologic changes.
Condition | Characteristics | Common location |
Uriticaria |
- Pruritic round pink to flesh colored plaques of varying sizes - More common in patients with atopy - Can be triggered by medications, foods, and allergens |
Generalized |
Fixed drug eruption |
- Solitary, round, well demarcated, bright red to dusky erythemic macules or plaques - Can form bullous lesions - Typically blister, crust or desquamate - Associated with pruritis and burning - Continue to reoccur in same place with subsequent exposure |
- Genitalia and perianal areas are most common - Can be generalized |
Stevens-Johnson syndrome |
- Atypical erthemic, dusky red target lesions - or macular pruritic lesions - associated with skin tenderness and burning - Lesions coalesce - Erosions and bullous lesions may be present on mucosal surfaces |
- Central face, trunk, and proximal extremities - Mucocutaneous - Eye involvement possible |
Erythema multiforme |
- Classically, erythemic, dusky red target lesions - Erythemic macules, papules, lesions resembling urticarial, vesicles, and bullae are also common - Pruritis and burning sensation - Bullous lesions and erosions found in the oral area |
- Symmetric on distal extremities - palmar and plantar surface |
Bullous pemphigoid |
- Erythemic, pruritic, urticarial like papules that coalesce into plaques, eventually forming bullous lesions - Once ruptured, an eroded base is left behind that will crust - Nikolsky sign negative - Typically seen in adults over age 60 |
- Skin folds, flexural surfaces, dependent areas - Can be generalized |