Case 1

Case 2

Case 3

Reference

Age at diagnosis (years)

64

64

48

Age at symptom onset (years)

64

60

43

Race

Caucasian

Caucasian

Caucasian

Travel in classic KS areas (high prevalence HHV-8 areas)

Yes

Yes

Yes

Smoking

No

No

No

Sexual history

MSM, HIV-negative partner, non-monogamous relationship

MSM, HIV-positive partner (with undetectable viral load), monogamous relationship

MSM, HIV-positive partner (with undetectable viral load), non-monogamous relationship

Taking PrEP

Yes

No

Yes

Medical history

No notable

Syphilis

Syphilis

Comorbidities

No notable

Venous insufficiency,

hypertension,

liver fibrosis

Recurrent genital herpes, hay fever

Localization (number of cutaneous lesions)

Lower limbs

Upper limbs

Mucosa

Face and Neck

Trunk

5-20

1-5

0

0

1-5

> 50

5-10

0

0

0

1-5

1-5

0

0

5-10

Lymph node/visceral involvement

No

No

No

Systemic therapy need

+/-

Yes

No

Total lymphocytes (/μL)

1880

1420

1880

1230-3420

B-lymphocytes (/μL)

126

77

128

100-500

CD4 T-cells (/μL)

748

542

641

300-1400

CD4/CD8 ratio

1.10

1.58

0.90

1.0-3.6