Systemic treatment

Number of patients (n)

Response (n)

Local recurrence (n)

Interferon alfa [4,19,22]

7

· Partial (4)

· Complete (3)

· Reported (1)

· No (1)

· NR (5)

Chemotherapy (vinblastine and bleomycin) [4,5,19,20]

5

· Partial (2)

· Complete (1)

· No (1)

· NR (1)

· NR (5)

Local treatment

Imiquimod cream [4,22]

8

· NR (8)

· NR (8)

Tretinoin and imiquimod cream [17]

1

· Complete (1)

· NR (1)

Cryotherapy [4,19,20]

5

· Complete (1)

· NR (4)

· No (1)

· NR (4)

CO2 laser [4]

1

· NR (1)

· NR (1)

Electrocauterization and curettage [19]

3

· Complete (2)

· NR (1)

· No (2)

· NR (1)

Surgery [4,5,16,18,19,21,22]/p>

24

· Complete (20)

· NR (4)

· No (3)

· NR (21)

Radiotherapy [4,5,19]

10

· Complete (3)

· NR (7)

· No (3)

· NR (7)

Topical cidofovir [22]

1

· NR (1)

· NR (1)