Function

Ref

Murine: - Neutrophil and monocyte chemotaxis (S100A8)

[43-56]

- Activate TLR4 and amplify inflammatory responses (S100A8)

[9]

- Inhibit macrophage spreading and phagocytosis of adherent

peritoneal cells (S100A9)

[57]

- Oxidant scavenger (S100A8)

[56]

- Reduce H₂O₂ release from activated macrophage (S100A9)

[58]

Human: - Neutrophil chemotaxis (S100A8/S100A9)

[43,44]

- Upregulate Mac-1 expression (S100A8? S100A9)

[43,44]

- Promote intercellular arachidonic acid transport (S100A8/S100A9)

[18]

- Antimicrobial defense (S100A8/S100A9)

[59]

- Inhibit fibrin formation (S100A9)

[60]

- Sequester intracellular Zn²⁺ (S100A8/S100A9)

[61]

- Oxidant scavenger and NO shuttle (S100A8)

[22,62]

- Reduce H₂O₂ release from activated macrophage (S100A9)

[58]

- Proinflammatory; enhance expression of proinflammatory cytokines

and adhesion molecules (S100A8/S100A9)

[63,64]

- Anti-inflammatory; recombinant proteins reduced LPS-induced systemic

release of IL-6 and NO in rats (S100A8/S100A9)

[65]

Association with inflammatory disease/disorder

Murine: - Arthritis (S100A8/S100A9)

[66]

- Abdominal sepsis

[55,67]

- Pneumonia-derived sepsis

[68]

- LPS-induced endotoxemia

[65,69]

- Autoimmune myocarditis

[70]

Human: - Arthritis (S100A8/S100A9)

[71-73]

- Inflammatory bowel disease (S100A8/S100A9)

[74]

- Systemic inflammation (S100A8/S100A9)

[75,76]

- Pancreatitis (S100A8/S100A9)

[77]

- Sepsis (S100A8/S100A9)

[67-79]

- Lupus erythematosus

[80]