Synopsis of patients with systemic adverse events.

Table 2: Synopsis of patients with systemic adverse events.

	Day of cluster regimen
	Day 0	Day 7	Day 14
Patient 1 (female, 7 years) Symptoms WAO grade Incubation period Treatment	Rhinitis I 30-45 minutes after 1^st injection Antihistamines p.o.	Rhinitis I 30-45 minutes after 1^st injection Antihistamines p.o.
Patient 2 (female, 7 years) Symptoms WAo grade Incubation period Treatment		Nausea I 60 minutes after 2^nd injection Antihistamines p.o.	Malaise^a I 60 minutes after 2^nd injection Antihistamines p.o.
Patient 3 (male, 18 years) Symptoms Wao grade Incubation period Treatment			Urticaria, dyspnea II 30 minutes after 2^nd injection Adrenalin inhalation, antihistamines i.v.