Table 2: Hyperplasia and marginal megakaryocytosis in spleen.
Control# | Vaccine# | Doxo# | Vaccine-Doxo# | ||
Red pulp† |
+ ++ +++ |
33% 67% 0% |
0% 100% 0% |
0% 100% 0% |
0% 100% 0% |
White pulp† |
+ ++ +++ |
67% 33% 0% |
33% 67% 0% |
100% 0% 0% |
33% 33% 33% |
Marginal megakaryocyte†† |
+ ++ +++ |
33% 33% 33% |
0% 100% 0% |
0% 67% 33% |
33% 67% 0% |
#Each column shows the percentage of mice from each group that presented de degree of histological alterations.
†Hyperplasia of red and white pulp was qualitatively evaluated as slight (+), moderate (++) or severe (+++).
††The presence of marginal megakaryocytes was qualitatively expressed as slight (+), moderate (++) or severe (+++).