Table 2: Hyperplasia and marginal megakaryocytosis in spleen.

Control# Vaccine# Doxo# Vaccine-Doxo#
Red pulp


+
++
+++
33%
67%
0%
0%
100%
0%
0%
100%
0%
0%
100%
0%
White pulp


+
++
+++
67%
33%
0%
33%
67%
0%
100%
0%
0%
33%
33%
33%
Marginal megakaryocyte††


+
++
+++
33%
33%
33%
0%
100%
0%
0%
67%
33%
33%
67%
0%

#Each column shows the percentage of mice from each group that presented de degree of histological alterations.
Hyperplasia of red and white pulp was qualitatively evaluated as slight (+), moderate (++) or severe (+++).
††The presence of marginal megakaryocytes was qualitatively expressed as slight (+), moderate (++) or severe (+++).