Table 1: Checkpoint molecules and their specific antibodies.
| Checkpoint Molecule | Specific Antibody | Nature of Antibody | (Trade name) and producer |
|---|---|---|---|
| CTLA-4 | Ipilimumab | Human, IgG1κ | Yervoy®, Bristol-Myers Squibb |
| Tremelimumab | Human, IgG2κ | Pfizer, Astra-Zeneca | |
| PD-1 | Nivolumab | Human, IgG4κ | Opdivo®, Bristol-Myers Squibb |
| Pembrolizumab | Humanized mouse, IgG4κ | Keytruda®, Merck | |
| PD-L1 | Pidilizumab | Humanized mouse, IgG1κ | Medivation (Pfizer) |
| Atezolizumab | Humanized IgG1κ | Tecentriq®, Genentech | |
| Avelumab | Humanized IgG1λ | Bavencio®, Merck, KGaA and Pfizer | |
| Durvalumab | Humanized IgG1κ | Imfinzi™, AstraZeneca |