Table 2: Autoimmune toxicity.
| Grade | Signs and Symptoms |
|---|---|
| 0 | None |
| I | Serologic or other evidence of autoimmune reactions in an otherwise asymptomatic patient. No treatment is required. |
| II | Evidence of autoimmune reaction involving a non-essential organ or function requiring treatment, but not immunosuppressive drugs. |
| III | Reversible autoimmune reaction involving function of a major organ or other adverse event, requiring short-term immunosuppressive treatment. |
| IV | Progressive and irreversible autoimmune reaction causing major organ dysfunction, requiring long-term, high-dose immunosuppressive treatment. |
| V | Death |