Table 2: Autoimmune toxicity.
Grade | Signs and Symptoms |
---|---|
0 | None |
I | Serologic or other evidence of autoimmune reactions in an otherwise asymptomatic patient. No treatment is required. |
II | Evidence of autoimmune reaction involving a non-essential organ or function requiring treatment, but not immunosuppressive drugs. |
III | Reversible autoimmune reaction involving function of a major organ or other adverse event, requiring short-term immunosuppressive treatment. |
IV | Progressive and irreversible autoimmune reaction causing major organ dysfunction, requiring long-term, high-dose immunosuppressive treatment. |
V | Death |