Table 3: AIRE deficiency symptoms compared to checkpoint inhibition immune-related adverse events.
| AIRE deficiency/APECED | Checkpoint inhibition | |
|---|---|---|
| Rash | X | X |
| Candidiasis | X | |
| Pruritis | X | |
| Vitiligo | X | X |
| Diarrhea | X | X |
| Colitis | X | |
| Constipation | X | X |
| Pernicious anemia | X | |
| Hypothyroidism | X | X |
| Fatigue | X | X |
| Increased Aminotransferases | X | |
| Pneumonitis | X | |
| Hypogonadism | X | |
| Adrenal Insufficiency | X | X |
| Parathyroid Insufficiency | X | |
| Hepatitis | X | X |
| Arthralgia | X | |
| Malabsorption | X |
X- Indicates that the symptom is present.