Table 1: Concentration-dependent inhibition percent of superoxide anion generation and neutrophil peroxidase (NPO) release of asthmatic patient neutrophil by total flavonoid extract of P. kotschyi.
Total flavonoid extract (µg.ml-1) |
NPO release inhibition (%) |
P value |
Superoxide anion generation inhibition (%) |
P value |
8 |
5.89 ± 7.86 |
ns |
2.62 ± 2.42 |
ns |
16 |
18.28 ± 8.34 |
* |
9.63 ± 3.50 |
ns |
32 |
31.62 ± 6.87 |
*** |
19.70 ± 7.07 |
ns |
64 |
54.53 ± 12.13 |
*** |
34.01 ± 20.44 |
** |
128 |
72.29 ± 5.69 |
*** |
79.31 ± 8.62 |
*** |
IC50 |
76.03 ± 12.81 |
|
84.89 ± 11.95 |
|
*p < 0.05, **p < 0.01, ***p < 0.001 compared with effect of fMLP (10 mM.ml-1) which was 0% inhibition; Ns: No difference.