Table 2: Effect of total flavonoids extract of P. kotschyi on production of TNF-α and LTB4 by asthmatic patient neutrophil.
Total flavonoid extract (µg.ml-1) |
TNF-α production inhibition (%) |
P value |
LTB4 production inhibition (%) |
P value |
8 |
9.09 ± 4.54 |
ns |
6.98 ± 3.85 |
ns |
16 |
24.12 ± 8.89 |
*** |
26.62 ± 0.54 |
*** |
32 |
44.08 ± 7.45 |
*** |
51.49 ± 5.95 |
*** |
64 |
66.48 ± 4.76 |
*** |
67.46 ± 3.80 |
*** |
128 |
85.83 ± 9.66 |
*** |
89.06 ± 6.48 |
*** |
IC50 |
54.07 ± 13.16 |
|
48.97 ± 3.33 |
|
***p < 0.001 compared with effect of fMLP (10 mM.ml-1) which was 0% inhibition; Ns: No difference.