Table 3: Inhibitory effect of total flavonoid extract of P. kotschyi on histamine-induced nitric oxide and hydrogen peroxide production by asthmatic patient neutrophil.
Total flavonoid extract (µg.ml-1) |
NO production inhibition (%) |
P value |
H2O2 production inhibition (%) |
P value |
8 |
13.26 ± 3.67 |
** |
11.21 ± 5.90 |
ns |
16 |
39.48 ± 8.36 |
*** |
35.12 ± 8.82 |
*** |
32 |
51.88 ± 5.04 |
*** |
62.91 ± 11.48 |
*** |
64 |
69.01 ± 2.71 |
*** |
85.65 ± 11.53 |
*** |
128 |
98.52 ± 0.58 |
*** |
97.30 ± 2.18 |
*** |
IC50 |
37.31 ± 4.11 |
|
32.05 ± 7.62 |
|
**p < 0.01, ***p < 0.001 compared with the effect of histamine (16 mM.l-1) which was 0% inhibition; Ns: No difference.