Table 1: Mechanisms of airflow obstruction in patients with neutrophilic asthma.
Airway neutrophil recruitment, Migration, and Activation |
Release of cytokines, Chemokines, Growth factors, and Adhesion molecules |
Airway epithelial damage and further release of cytokines |
Goblet cells hyperplasia and Mucus hypersecretion |
Airway hyperresponsiveness |
Subepithelial fibrosis |
Airway smooth muscle proliferation |
Airway remodeling |
Corticosteroid resistance |