Table 1: Mechanisms of airflow obstruction in patients with neutrophilic asthma.
| Airway neutrophil recruitment, Migration, and Activation |
| Release of cytokines, Chemokines, Growth factors, and Adhesion molecules |
| Airway epithelial damage and further release of cytokines |
| Goblet cells hyperplasia and Mucus hypersecretion |
| Airway hyperresponsiveness |
| Subepithelial fibrosis |
| Airway smooth muscle proliferation |
| Airway remodeling |
| Corticosteroid resistance |