Table 1: Different sizes particles can reach location in vivo [15].

Particle size

Can reach the location in vivo

> 12 mm

Can be blocked at the end of the capillary or stay in the liver, stomach, as well as in the organs with tumors

7~12 mm

Can be ingested by the lungs by intravenous injection

2~12 mm

Can be ingested by capillary network, not only can reach lung, but also can reach liver and spleen

1 mm

The size is most likely to be devoured by white blood cells

0.1~0.2 mm

Can be injected through the vein, artery or abdominal cavity, and in the reticuloendothelial system be absorbed by macrophages from the blood

< 50 nm

Can be transmitted through the liver endothelium or through lymph to the spleen, and can also reach bone marrow, as well as tumor tissue and liver