Table 1: Examples of FDA-approved medicaments that use spray drying technology as preparation method.
HPMC: Hydroxypropyl Methylcellulose; HPMCAS: Hydroxypropyl Methylcellulose Acetate Succinate; DSPC: Distear-ylphosphatidylcholine (data summarized from [2-8]).
Trade name | Drug | Application | Polymer, Excipient | Maximum drug dose | Company | FDA approval |
Prograf | Tacrolimus | Immunosuppressant (prevents organ rejection) | HPMC | 5 mg per capsule | Astellas Pharma | 1994 |
Exhubera | Insulin | Diabetes | Mannitol, glycine, sodium citrate | 1 or 3 mg per capsule | Pfizer/Nektar | 2006 |
Intelence | Etravirine | HIV medicine | HPMC | 100 or 200 mg per tablet | Janssen | 2008 |
Zortress | Everolimus | Immunosuppressant (prevents organ rejection) | HPMC | 0.75 mg per tablet | Novartis | 2010 |
Aridol/Osmohale, Bronchitol | - | Asthma/Cystic fibrosis | Mannitol | 5 to 40 mg per capsule | Pharmaxis | 2010 |
Incivek | Telaprevir | Hepatitis C | HPMCAS | 375 mg per tablet | Vertex | 2011 |
Kalydeco | Ivacaftor | Cystic fibrosis | HPMCAS | 150 mg per tablet | Vertex | 2012 |
TOBI Podhaler | Tobramycin | Inhalation therapy | DSPC, calcium chloride, sulfuric acid | 28 mg per capsule | Novartis | 2013 |
Raplixa | - | Bleeding control during surgery | Fibrinogen/Thrombin | 79 mg/726 IU per gram powder | Nova Laboratories | 2016 |