Table 6: Typical first-guess experimental process parameters for nano spray drying of pharmaceuticals.
Solvent | Inlet drying temperature [℃] | Outlet drying temperature [℃] | Drying gas type | Drying gas flow rate [L/min] | Solid concentration [% w/v] | Spray mesh size [µm] | Feed Rate [mL/h] |
Water Ethanol Acetone DCM |
60 to 120 50 to 110 40 to 70 30 to 50 |
30 to 60 30 to 50 25 to 40 20 to 35 |
Air Air Inert gas (N2/CO2) |
100 to 140 100 to 120 90 to 120 80 to 120 |
0.1 to 10 |
4.0 5.5 7.0 |
5 to 25 20 to 65 30 to 160 |