Table 6: Typical first-guess experimental process parameters for nano spray drying of pharmaceuticals.

Solvent Inlet drying temperature [℃] Outlet drying temperature [℃] Drying gas type Drying gas flow rate [L/min] Solid concentration [% w/v] Spray mesh size [µm] Feed Rate [mL/h]

Water

Ethanol

Acetone

DCM

60 to 120

50 to 110

40 to 70

30 to 50

30 to 60

30 to 50

25 to 40

20 to 35

Air

Air

Inert gas

(N2/CO2)

100 to 140

100 to 120

90 to 120

80 to 120

0.1 to 10

4.0

5.5

7.0

5 to 25

20 to 65

30 to 160