Table 2: List of advantages and drawbacks of chitosan nanoparticulate dosage form.
Advantages |
Disadvantages |
Toxicity is less |
Mechanical resistance is less |
Enhanced Biocompatibility |
Difficulty in controlling pore size |
Possess mucoadhesive character |
May contract |
Possess stability |
Electrospinning is difficult for pure chitosan |
Drug targeting is site-specific |
Preparation by crosslinking can affect intrinsic properties of chitosan |
Therapeutic index of the drug is increased |
Low solubility in neutral and alkaline pH |
Frequent, expensive and unpleasant dosing is prevented |
Method of preparation must be changed according to the drug to be delivered |