Table 2: Locations and times where α-syn was located following gastrointestinal (GI) injections. Following the injection of α-syn into the GI tracts in various paradigms animals were sacked at period of hours postinjection (HPI), days postinjection (DPI) and months postinjection (MPI). Thereafter, the various studies located α-syn in the GI, vagus nerve (VN), dorsal motor nucleus of the vagus (DMV), locus coeruleus (LC), substantia nigra pars compacts (SNpc), amygdale (AM), olfactory bulbs (OB), hippocampus (HC), striatum (ST), hypothalamus (HT), entorhinal cortex (EC), motor cortex (MC), and prefrontal cortex (PFC). In some instances, α-syn pathology was not observed (NO) as in non-human primates (NHPs). Citation number denoted in parenthesis.
α-syn Immunoreactivity Locations and Times |
|||||||||||||||
|
GI |
VN |
DMV |
LC |
SNpc |
AM |
MO |
OB |
HC |
ST |
HT |
EC |
MC |
PFC |
|
Holmqvist, et al. [111] |
12 HPI |
48 144 HP1 |
144 HP1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
Manfredsson, et al. [112] |
1- 12 MP1 |
- |
1 MPI NO 12 MPI) (NHPs |
1 MPI |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
Uemura, et al. [113] |
45 DPI |
- |
45 DPI |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
|
Van Den Berge, et al. [114] |
4 MPI |
- |
4 MPI |
4 MPI |
4 MPI |
- |
- |
4 MPI |
4 MPI |
4 MPI |
4 MPI |
4 MPI |
4 MPI |
- |
|
Kim, et al. [115] |
1
MPI |
- |
1-10 MPI |
1 MPI |
3, 7 MPI |
3 MPI |
1- 10 MPI |
1- 10 MPI |
7 & 10 MPI |
7 & 10 MPI |
7 MPI |
- |
- |
3, 7, & 10 MPI |
|
Challis, et al. [116] |
21- 120 DPI |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |