Table 2: Locations and times where α-syn was located following gastrointestinal (GI) injections. Following the injection of α-syn into the GI tracts in various paradigms animals were sacked at period of hours postinjection (HPI), days postinjection (DPI) and months postinjection (MPI). Thereafter, the various studies located α-syn in the GI, vagus nerve (VN), dorsal motor nucleus of the vagus (DMV), locus coeruleus (LC), substantia nigra pars compacts (SNpc), amygdale (AM), olfactory bulbs (OB), hippocampus (HC), striatum (ST), hypothalamus (HT), entorhinal cortex (EC), motor cortex (MC), and prefrontal cortex (PFC). In some instances, α-syn pathology was not observed (NO) as in non-human primates (NHPs). Citation number denoted in parenthesis.

α-syn Immunoreactivity Locations and Times

 

GI

VN

DMV

LC

SNpc

AM

MO

OB

HC

ST

HT

EC

MC

PFC

Holmqvist, et al. [111]

12

HPI

48

144

HP1

144

HP1

-

-

-

-

-

-

-

-

-

-

-

Manfredsson, et al. [112]

1-

12

MP1

-

1 MPI

NO 12

MPI)

(NHPs

1

MPI

-

-

-

-

-

-

-

-

-

-

Uemura, et al. [113]

45

DPI

-

45

DPI

-

-

-

-

-

-

-

-

-

-

-

Van Den Berge, et al. [114]

4

MPI

-

4 MPI

4 MPI

4 MPI

-

-

4 MPI

4 MPI

4 MPI

4 MPI

4 MPI

4 MPI

-

Kim, et al. [115]

1

 

MPI

-

1-10 MPI

1

MPI

3, 7

MPI

3

MPI

1-

10

MPI

1-

10

MPI

7 &

10

MPI

7 &

10

MPI

7

MPI

-

-

3, 7,

& 10

MPI

Challis, et al. [116]

21-

120

DPI

-

-

-

-

-

-

-

-

-

-

-

-

-