Table 1: The twenty most up-regulated genes and their functions following treatment of BV2 microglia cells with FL-ApoE4 (Greater than > 2-fold change, p < 0.05).
Gene Symbol |
Gene Name |
Fold Change |
Function |
Gm33661 |
Predicted Gene, 33661 |
154 |
|
Pcsk5 |
Protein Convertase Sub-tilisin/Kevin Type 5 |
22.5 |
Among its related pathways are lipoprotein metabolism |
Serpina3f |
Serpin Family A Member 3 |
4.66 |
Plasma protease inhibitor and inhibits neutrophil cathepsin G |
Gm35200 |
Predicted Gene, 35200 |
3.15 |
|
Gm36319 |
Predicted Gene, 36319 |
2.77 |
|
Serpina3g |
Serine Protease Inhibitor A3G |
2.71 |
Serine and cysteine protease inhibitor |
Slfn5 |
Schlafen Family member 5 |
2.63 |
May have a role in hematopoietic cell differentiation |
Adam33 |
ADAM Metallopeptidase Domain 33 |
2.62 |
Membrane-anchored disintegrin involved in cell-matrix interactions |
Gm32124 |
Predicted Gene 32124 |
2.41 |
|
Siglece |
Sailic Acid-binding Ig-like Lectin 12 |
2.35 |
Adhesion molecule that may be an inhibitory receptor in immune cells |
Cx3cr1 |
CX3C chemokine receptor 1 |
2.32 |
In immune cells, mediates both adhesive and migratory functions |
Gcm2 |
Glial Cells Missing Tran-scription Factor 2 |
2.30 |
Acts as a binary switch between neuronal and glial cell determination |
P2ry6 |
Pyrimidergic Receptor P2Y6 |
2.28 |
P2 receptor that mediates inflammatory responses |
Usp18 |
Ubiquitin Specific Peptidase 18 |
2.24 |
Cleaves ubiquitin on protein substrates and downregulates interferon responses |
Oas2 |
2’-5’-Oligoadenylate Synthetase 2 |
2.19 |
Essential protein involved in the innate immune response to viral infection |
Irf7 |
Interferon Regulatory Factor 7 |
2.14 |
Plays a critical role in the innate immune response against viruses |
Gm32006 |
Predicted Gene, 32006 |
2.11 |
|
Gm5431 |
Programmed Cell Death 1 |
2.10 |
|
Pdcd1 |
Kinesin Family Member 5C |
2.08 |
Cell surface protein that plays a role in maintenance of immune tolerance to self |
Kif5c |
|
2.01 |
Involved in the transport of cargo within the CNS |