Table 1: The twenty most up-regulated genes and their functions following treatment of BV2 microglia cells with FL-ApoE4 (Greater than > 2-fold change, p < 0.05).

Gene Symbol

Gene Name

Fold Change

Function

Gm33661

Predicted Gene, 33661

154

 

Pcsk5

Protein Convertase Sub-tilisin/Kevin Type 5

22.5

Among its related pathways are lipoprotein metabolism

Serpina3f

Serpin Family A Member 3

4.66

Plasma protease inhibitor and inhibits neutrophil cathepsin G

Gm35200

Predicted Gene, 35200

3.15

 

Gm36319

Predicted Gene, 36319

2.77

 

Serpina3g

Serine Protease Inhibitor A3G

2.71

Serine and cysteine protease inhibitor

Slfn5

Schlafen Family member 5

2.63

May have a role in hematopoietic cell differentiation

Adam33

ADAM Metallopeptidase Domain 33

2.62

Membrane-anchored disintegrin involved in cell-matrix interactions

Gm32124

Predicted Gene 32124

2.41

 

Siglece

Sailic Acid-binding Ig-like Lectin 12

2.35

Adhesion molecule that may be an inhibitory receptor in immune cells

Cx3cr1

CX3C chemokine receptor 1

2.32

In immune cells, mediates both adhesive and migratory functions

Gcm2

Glial Cells Missing Tran-scription Factor 2

2.30

Acts as a binary switch between neuronal and glial cell determination

P2ry6

Pyrimidergic Receptor P2Y6

2.28

P2 receptor that mediates inflammatory responses

Usp18

Ubiquitin Specific Peptidase 18

2.24

Cleaves ubiquitin on protein substrates and downregulates interferon responses

Oas2

2’-5’-Oligoadenylate Synthetase 2

2.19

Essential protein involved in the innate immune response to viral infection

Irf7

Interferon Regulatory Factor 7

2.14

Plays a critical role in the innate immune response against viruses

Gm32006

Predicted Gene, 32006

2.11

 

Gm5431

Programmed Cell Death 1

2.10

 

Pdcd1

Kinesin Family Member 5C

2.08

Cell surface protein that plays a role in maintenance of immune tolerance to self

Kif5c

 

2.01

Involved in the transport of cargo within the CNS