Table 2: The fifteen most down-regulated genes and their functions following treatment of BV2 microglia cells with FL-ApoE4 (Greater than < 2-fold change, p < 0.05).
Gene Symbol |
Gene Name |
Fold Change |
Function |
Il27 |
Interleukin 27 |
-5.69 |
Cytokine that is known to synergize with IL12B to trigger IFNG production |
Il23a |
Interleukin 23 Subunit Alpha |
-4.00 |
Cytokine that is important part of the inflammatory response against infection |
Gdf15 |
Growth Differentiation Factor 15 |
-3.69 |
Ligand of the TGF-beta super-family that regulates inflammatory pathways |
Dmd |
Dystrophin |
-3.40 |
Cytoskeletal protein in muscle cells that provides for tensile strength |
Nr4a3 |
Nuclear Receptor Subfamily 4 Group A Member 3 |
-3.38 |
Protein that is a member of the thyroid hormone receptor and may act as a transcriptional activator |
Mir155hg |
MicroRNA Host Gene 2 |
-3.22 |
Non-protein coding microRNA |
Dusp8 |
Dual Specificity Phophatase 8 |
-3.13 |
Phosphatase that negatively regulates members of the MAP kinase family. |
Nfkbiz |
NF-Kappa-B Inhibitor Zeta |
-2.91 |
Plays a role in inflammatory responses to LPS |
Chac1 |
Glutathione-specific Gamma-glutamylcyclotransferase 1 |
-2.90 |
Catalyzes the cleavage of glutathione |
Gm40447 |
Predicted Gene 40447 |
-2.88 |
No known function at this time |
Ptprd |
Receptor-type Tyrosine-protein Phosphatase delta |
-2.85 |
Involve in neuronal differentiation and may act as a tumor suppressor |
Sstr5 |
Somatostatin Receptor Type 5 |
-2.76 |
May increase cell growth inhibition |
Tnfsf9 |
Tumor Necrosis Factor Ligand Superfamily 9 |
-2.75 |
Cytokine that Induces proliferation of activated peripheral blood T-cells |
Ddit4 |
DNA Damage-inducible Transcript 4 Protein |
-2.66 |
Regulates cell growth, proliferation and survival via inhibition of mTORC1 |
Phlda1 |
Pleckstrin Homology-like Domain Family A1 |
-2.64 |
Mediates apoptosis via increased sensitivity to chemotherapeutic agents |