| Periphery | CNS |
| 1. Antigen presentation to CD4+ prompting activation and proliferation of inflammatory T cells (Th1 and Th17) 2. Secretion of pro-inflammatory cytokines 3. Up-regulation of adhesion molecules 4. Disruption of blood brain barrier 5. T cell migration into CNS 6. B cell activation, proliferation and migration into CNS 7. Inadequate T regulatory function |
8. Presentation of CNS Antigen to T cell with reactivation 9. Recruitment of other inflammatory cells : CD 8+, B cells, monocytes, macrophages, microglia 10. Damage to myelin, oligodendrocytes and axons resulting from: cytokine damage, Ab activity, complement damage, oxidative stress mitochondrial dysfunction |