Table 1: Effect of topical ocular (R)-WIN-64338 on Dutch-belt rabbit IOP

Compound	Time after topical ocular dosing (Hours)	% Change in IOP from Baseline and/or Vehicle
(R)-WIN-64338 (300μMg; 1%)	0	0
	0.5	-8.3 ± 2.5%
	1	-3.9 ± 2.3%
	2	-4.8 ± 2.7%
	3	-8.9 ± 5.0%
	4	9.1 ± 1.3%
	5	-2.9 ± 1.5%

(R)-WIN-64338 (300μMg; 1%) was applied topical ocularly to the eyes of 7 pigmented Dutch-Belted rabbits as a single 30μMl drop and IOP monitored over time. The vehicle did not modify the IOP to any significant degree over the 5 hr period (max change in IOP=-4.1 ± 4.2%), and no contralateral effects of either the vehicle or (R)-WIN-64338 were observed.