Table 7: Expression of iron regulatory genes in FHL124 cells upon iron challenge.
| Expression of target genes (fold change to control, mean ± S.E. (p)) | |||||||||
| Iron Uptake and Import | Iron Storage and Export | Iron homeostasis | |||||||
| Treatment Group (n) | NIRE-DMT1 | RE-DMT1 | TFR2 | FTH | FTL | FPN | IRP1 | RP2 | FBXL5 |
| 150 μM (3) | 1.89 ± 0.07 | 3.56 ± 0.95 | 0.58 ± 0.18 | 0.72 ± 1.02 | 0.84 ± 1.07 | 1.80 ± 0.74 | 0.51 ± 0.60 | 0.63 ± 2.33 | 1.30 ± 0.96 |
| (p=0.04) | (p=0.01) | (p=0.28) | (p=0.01) | (p=0.31) | (p=0.20) | (p=0.38) | (p=0.69) | (p=0.13) | |
| 250 μM (3) | 2.66 ± 0.06 | 1.60 ± 1.00 | 0.37 ± 0.08 | 0.73 ± 1.05 | 1.09 ± 0.99 | 3.56 ± 1.03 | 0.99 ± 0.57 | 2.46 ± 1.03 | 2.67 ± 1.06 |
| (p=0.04) | (p=0.18) | (p=0.42) | (p=0.02) | (p=0.40) | (p=0.08) | (p=0.99) | (p=0.06) | (p=0.00) | |
| 500 μM (3) | 4.96 ± 0.08 | 0.43 ± 0.09 | 0.28 ± 0.02 | 1.83 ± 1.02 | 2.43 ± 1.02 | 7.47 ± 0.90 | 1.48 ± 0.53 | 3.57 ± 1.74 | 3.10 ± 0.98 |
| (p=0.03) | (p=0.02) | (p=0.22) | (p=0.0005) | (p=0.0013) | (p=0.012) | (p=0.59) | (p=0.19) | (p=0.00) | |
N: Number of replicates, p = p-value.