Table 1: Pharmacokinetic parameters.
| Total Platinum | Free Platinum | |||||
|
Cycle (Oxaliplatin dose) |
C0 (μg/mL) |
Cmax (μg/mL) |
AUC0-48 (μg*h/mL) |
C0 (μg/mL) |
Cmax (μg/mL) |
AUC0-48 (μg*h/mL) |
|
First cycle (42.5 mg/m2) |
0 |
1.4 |
44.0 |
0 |
0.73 |
14.2 |
|
Second cycle (42.5 mg/m2) |
0.2 |
2.0 |
－ |
0.02 |
0.80 |
－ |
|
Third cycle (50 mg/m2) |
0.3 |
1.7 |
－ |
0.04 |
1.03 |
－ |
|
Normal function (85 mg/m2)* |
－ |
－ |
－ |
0 |
0.93 |
10.9 |
*Data from Japanese package insert;
C0: Initial concentration; Cmax: Maximum concentration; AUC0-48: Area under the curve from 0 to 48 hours.