Table 2: Multivariate Cox regression models.
|
cfDNA T1 |
|
FFPE DNA |
|
HR (95% CI) |
P value |
HR (95% CI) |
P value |
|
Number of detected mutations |
|
|
|
|
ALK (0 vs. ≥1) |
0.476 (0.300–0.755) |
0.002 |
0.595 (0.335–1.059) |
0.077 |
EGFR (0 vs. ≥1) |
0.634 (0.384–1.045) |
0.074 |
0.683 (0.402–1.160) |
0.158 |
KRAS (0 vs. ≥1) |
1.512 (0.907–2.519) |
0.113 |
0.801 (0.465–1.380) |
0.424 |
Overall* (0 vs. ≥1) |
0.477 (0.313–0.727) |
0.0006 |
0.881 (0.497–1.559) |
0.662 |
VAF groups* |
|
|
|
|
VAF<5% vs. no mutation |
2.758 (1.710–4.446) |
3.16×10-5 |
1.067 (0.573–1.986) |
0.838 |
VAF<5% vs. VAF≥5% |
3.510 (1.672–7.370) |
0.0009 |
0.860 (0.458–1.614) |
0.638 |
Mutation types* |
|
|
|
|
Missense vs. no mutation |
2.156 (1.332–3.489) |
0.002 |
1.128 (0.600–2.121) |
0.708 |
Missense vs. other type |
1.081 (0.582–2.008) |
0.806 |
0.985 (0.528–1.838) |
0.961 |
Concentration |
cfDNA T1 |
|
cfDNA T2 |
|
<0.6 vs. ≥0.6 ng/μL |
1.670 (1.108–2.516) |
0.014 |
|
|
<0.75 vs. ≥0.75 ng/μL |
|
|
1.507 (0.581–3.910) |
0.399 |
*For mutations detected in eight genes (ALK , AKT1 , BRAF , EGFR , ERBB2 , MET , NRAS , and PIK3CA );
cfDNA: cell-free DNA; FFPE: Formalin-Fixed Paraffin-Embedded; HR: Hazard Ratio; CI: Confidence Interval; VAF: Variant Allele Frequency