Table 1: List of significantly altered metabolites in prostate tissue associated with tumor TME using NMR spectroscopy-based metabolic profiling.
|
Tissue samples (Prostate tumor tissue) |
NMR methods |
Significant Altered metabolites in prostate tissue associated with TME |
References |
|
Low RSG (n = 58) and high RSG (n = 27) |
1H- NMR and 31P-NMR |
α-Glucose, NAD+, Arginine, Succinate/Malate Lysophosphatidylcholine, Phosphatidylethanolamine Sphingomyelin |
[9] |
|
PCa Patients (n = 16) Benign (n = 59) |
1H-NMR |
Citrate and spermine taurine, scyllo-inositol and leucine |
[10] |
|
Patients with BPH (n = 18), EPC (n = 16), APC (n = 11), MPC (n = 23), and CRPC (n = 8) |
1H-NMR |
Citrate, creatinine, acetate, leucine, valine, glycine, lysine, histidine, glutamine choline uridine, and formate. |
[8] |
|
NAD+: Nicotinamide Adenine Dinucleotide; TME: Tumor Microenvironment; RSG: Reactive Stromal Grading; BPH: Benign Prostatic Hyperplasia; EPC: Early PCa; APC: Advanced PCa; MPC: Metastatic PCa; CRPC: Castration-Resistant PCa |
|||