Table 3: Comparison of patient’s characteristics: low-grade versus high-grade PanIN (n = 729).
|
Characteristics |
All patients (n = 729) |
PanIN |
|
|
|
Low grade PanIN (n = 657) |
High-grade PanIN (n = 72) |
P value |
||
|
Age (in years), median |
64 [IQR: 56-72] |
64 [IQR: 56-72] |
65 [IQR: 56-75] |
0.4363a |
|
Gender |
|
|
|
|
|
Female |
349 (48) |
316 (48) |
33 (46) |
0.715b |
|
Male |
380 (52) |
341 (52) |
39 (54) |
|
|
Diagnosis |
|
|
|
|
|
Pancreatic ductal adenocarcinoma |
312 (43) |
242 (37) |
70 (97) |
< 0.0001*c |
|
IPMN |
62 (8) |
60 (9) |
2 (3) |
|
|
Others (MCN, Neuroendocrine, non-ductal, non-pancreatic, non-tumoral) |
355 (49) |
355 (54) |
0 |
|
|
Smoking history [n = 722] |
|
|
|
|
|
No |
577 (80) |
519 (80) |
58 (83) |
0.518b |
|
Yes |
145 (20) |
133 (20) |
12 (17) |
|
|
Alcohol intake history [n = 722] |
|
|
|
|
|
No |
589 (82) |
531 (81) |
58 (83) |
0.772b |
|
Yes |
133 (18) |
121 (19) |
12 (17) |
|
|
Diabetes [n = 722] |
|
|
|
|
|
No |
515 (71) |
467 (72) |
48 (69) |
0.591b |
|
Yes |
207 (29) |
185 (28) |
22 (31) |
|
aMann Whitney U test was used; bChi square test was used; cFisher’s Exact test was used
PanIN: Pancreatic Intraepithelial Neoplasia; IQR: Interquartile Range; IPMN: Intraductal Papillary Mucinous Neoplasm; MCN: Mucinous Cystic Neoplasm