Table 1: The concentration of metabolites (mM) in blood plasma samples of PCa patients with GS ≥ 7 and GS < 7. AUC values were obtained in univariate ROC curve analyses and VIP scores
|
S.No. |
Metabolites |
Metabolite concentration(mM) |
p-value |
AUC |
VIP Score |
|
|
PCa with GS ≥ 7 N = 35 (Mean ± SD) |
PCa with GS < 7 N = 15 (Mean ± SD) |
|||||
|
1 |
Leucine |
0.78 (0.53-1.88) |
0.90 (0.43-1.18) |
0.36 |
0.68
|
0.69
|
|
2 |
Valine |
0.28 (0.11-0.66) |
0.34 (0.14-0.43) |
0.31 |
0.67
|
0.76
|
|
3 |
Isoleucine |
0.34 (0.12-0.79) |
0.37 (0.19-0.52) |
0.22 |
0.71
|
0.92 |
|
4 |
3HOB |
0.55 (0.21-1.31) |
0.59 (0.25-0.80) |
0.62 |
0.55
|
0.02
|
|
5 |
Lactate |
3.26 (1.50-7.53) |
2.29 (1.31-4.43) |
0.04 |
0.67
|
1.37
|
|
6 |
Alanine |
0.60 (0.37-1.24) |
0.54 (0.30-1.00) |
0.19 |
0.66
|
1.05
|
|
7 |
Acetate |
0.06 (0.02-0.17) |
0.06 (0.04-0.10) |
0.56 |
0.55
|
0.26
|
|
8 |
Acetoacetate |
0.10 (0.04-0.34) |
0.10 (0.04-0.22) |
0.52 |
0.52
|
0.35
|
|
9 |
Glutamate |
0.46 (0.35-0.97) |
0.43 (0.28-0.74) |
0.24 |
0.61
|
1.00
|
|
10 |
Pyruvate |
0.07 (0.04-0.23) |
0.06 (0.05-0.09) |
0.10 |
0.62
|
0.83 |
|
11 |
Glutamine |
0.86 (0.50-1.50) |
0.87 (0.53-1.48) |
0.87 |
0.51
|
0.16 |
|
12 |
DMA |
0.07 (0.03-0.13) |
0.06 (0.04-0.14) |
0.49 |
0.57
|
0.38
|
|
13 |
Creatine |
0.08 (0.05-0.16) |
0.08 (0.05-0.12) |
0.53 |
0.57
|
0.62 |
|
14 |
Phosphocreatine |
0.11 (0.01-0.64) |
0.05 (0.01-0.19) |
0.001 |
0.80
|
1.74
|
|
15 |
Malonate |
0.06 (0.03-0.24) |
0.06 (0.03-0.10) |
0.49 |
0.50
|
0.16
|
|
16 |
Choline |
0.11 (0.06-0.17) |
0.07 (0.05-0.11) |
0.001 |
0.75
|
1.88
|
|
17 |
GPC |
0.09 (0.04-0.22) |
0.09 (0.04-0.19) |
0.62 |
0.55
|
0.42
|
|
18 |
Glycine |
0.33 (0.17-0.78) |
0.31 (0.21-0.57) |
0.75 |
0.50
|
0.07
|
|
19 |
Creatinine |
0.15 (0.08-0.73) |
0.15 (0.09-0.27) |
0.14 |
0.52
|
0.50
|
|
20 |
Tyrosine |
0.18 (0.06-0.30) |
0.21 (0.09-0.32) |
0.04 |
0.66
|
1.36
|
|
21 |
Histidine |
0.11 (0.04-0.19) |
0.16 (0.07-0.25) |
0.005 |
0.76 |
2.09
|
|
22 |
Phenylalanine |
0.20 (0.07-0.33) |
0.23 (0.10-0.38) |
0.18 |
0.61
|
0.91 |
|
23 |
Glucose |
5.45 (2.75-9.38) |
4.51 (3.23-8-.32) |
0.11 |
0.65
|
1.16
|
|
24 |
Taurine |
1.27 (0.78-2.83) |
1.11 (0.71-1.68) |
0.05 |
0.63
|
1.10
|
|
25 |
Betaine |
0.21 (0.14-0.45) |
0.20 (0.14-0.28) |
0.15 |
0.60
|
0.94 |