Table 4: Results from the blood plasma metabolites associated with dominated altered metabolic pathway analysis of PCa patients using Metabolic Pathway Analysis (MetPA).

Altered Metabolic pathways

Total Compounds

Hits

Raw p

Holm p

FDR

Methylhistidine Metabolism

4

1

2.11E-03

1.18E-01

5.76E-02

Beta-Alanine Metabolism

34

2

4.44E-03

2.44E-01

5.76E-02

Histidine Metabolism

42

2

4.44E-03

2.44E-01

5.76E-02

Phospholipid Biosynthesis

29

1

6.17E-03

3.27E-01

5.76E-02

Phosphatidylcholine Biosynthesis

14

1

6.17E-03

3.27E-01

5.76E-02

Phosphatidylethanolamine Biosynthesis

12

1

6.17E-03

3.27E-01

5.76E-02

Betaine Metabolism

21

1

1.77E-02

8.86E-01

 

1.42E-01

Methionine Metabolism

42

3

4.61E-02

1.00E+00

2.65E-01

Gluconeogenesis

33

3

4.92E-02

1.00E+00

2.65E-01

Raw p is the original p value calculated from the enrichment analysis; Holm p is the p value adjusted by Holm-Bonferroni method; FDR p is the p-value adjusted using False Discovery Rate