Table 4: Results from the blood plasma metabolites associated with dominated altered metabolic pathway analysis of PCa patients using Metabolic Pathway Analysis (MetPA).
Altered Metabolic pathways |
Total Compounds |
Hits |
Raw p |
Holm p |
FDR |
Methylhistidine Metabolism |
4 |
1 |
2.11E-03 |
1.18E-01 |
5.76E-02 |
Beta-Alanine Metabolism |
34 |
2 |
4.44E-03 |
2.44E-01 |
5.76E-02 |
Histidine Metabolism |
42 |
2 |
4.44E-03 |
2.44E-01 |
5.76E-02 |
Phospholipid Biosynthesis |
29 |
1 |
6.17E-03 |
3.27E-01 |
5.76E-02 |
Phosphatidylcholine Biosynthesis |
14 |
1 |
6.17E-03 |
3.27E-01 |
5.76E-02 |
Phosphatidylethanolamine Biosynthesis |
12 |
1 |
6.17E-03 |
3.27E-01 |
5.76E-02 |
Betaine Metabolism |
21 |
1 |
1.77E-02 |
8.86E-01
|
1.42E-01 |
Methionine Metabolism |
42 |
3 |
4.61E-02 |
1.00E+00 |
2.65E-01 |
Gluconeogenesis |
33 |
3 |
4.92E-02 |
1.00E+00 |
2.65E-01 |
Raw p is the original p value calculated from the enrichment analysis; Holm p is the p value adjusted by Holm-Bonferroni method; FDR p is the p-value adjusted using False Discovery Rate