Table 1: Summary of Sea-Blue Histiocyte Syndrome etiologies

Summary of Sea Blue Histiocytosis Etiologies

Primary Sea Blue Histocytosis

·        No known cause after thorough investigation

Secondary Sea Blue Histiocytosis

·       Hematological Causes

o  Chronic myelogenous leukemia

o  Severe auto-immune neutropenia

o  Idiopathic thrombocytopenic purpura

o  Other hematological proliferative disorders

o  Infectious diseases with bone marrow involvement

·       Lipid and Ceroid Metabolic Causes

o  Niemann-Pick Disease

o  Lecithin cholesterol acyltransferase deficiency

o  Fabry Disease

o  Gaucher Disease

o  Hyperlipidemic conditions/disorders

·       Miscellaneous Causes

o  Batten’s disease

o  Neuroaxonal dystrophy

o  Takayasu’s arteritis

o  Posterior column dysfunction

o  Long-term parenteral nutrition with fat emulsion

o  Prolonged therapy with liposomal amphotericin B