Table 1: Physiological roles of catenin family proteins in neuronal functions.

 

Catenins

Biological function in neuron

Interacting proteins

α-catenin

Increase in spine density and stability [69]

vinculin [70]

β-catenin [70]

β-catenin

Regulation of glutamatergic receptor response [37]

Regulation of synaptic vesicle formation [16,71]

cadherins [7], α-catenin [70]

PS1 [6], scribble [71]

Cdk5 [72]

δ-catenin

Induction of dendritic morphology [36,40]

Regulation of spine morphology and synaptic

plasticity [10]

cadherins [15], PSD95 [15],

PS1 [40], cortactin [73]

p190 RhoGEF [74]

p120-catenin

Stabilization of surface levels of cadherins [75]

Regulation of spine and synapse morphogenesis [14,76]

Inhibition of RhoA activity [13]

cadherins [75], PS1 [7]

Fer [77], Fyn [77], cortactin [78]

p190 RhoGEF [79]

p0071

Regulation of neurite outgrowth and blanching [80]

PS1 [81], cadherins [82]