Table
1: Physiological
roles of catenin family proteins in neuronal functions.
Catenins |
Biological function in neuron |
Interacting proteins |
α-catenin |
Increase
in spine density and stability [69] |
vinculin [70] β-catenin [70] |
β-catenin |
Regulation of glutamatergic
receptor response [37] |
PS1
[6], scribble [71] Cdk5
[72] |
δ-catenin |
Induction
of dendritic morphology [36,40] Regulation
of spine morphology and synaptic plasticity
[10] |
p190
RhoGEF [74] |
p120-catenin |
Stabilization
of surface levels of cadherins [75] Regulation of spine and synapse morphogenesis [14,76] Inhibition
of RhoA activity [13] |
Fer [77], Fyn [77], cortactin [78] p190
RhoGEF [79] |
p0071 |
Regulation of neurite outgrowth
and blanching [80] |