Table 3: Immunohistochemistry results, according immunoexpression in tumoral cells and brain invasion.

Brain invasion n = 51 (%) Non invasion n = 49 (%) P value
Ki67 external epithelium 16.71 ± 3.60 16.51 ± 3.75 0.100
Ki67 reticulum stellate 25.12 ± 9.02 26.12 ± 9.03 0.251
Ki67 nest invasión 32.04 ± 6.57 16.68 ± 4.0 0.000
MVD-li (CD34) intratumoral 4.84 ± 1.06 4.88 ± 1.01 0.462
MVD-Li (CD34) peritumoral 17.98 ± 4.67 14.84 ± 5.16 0.017

Keratin 7 tumoral

 

41 (80)

 

40 (82)

 

0.539

cc.016
Keratin7 in nest/invasion 3 (6) 2 (4) 0.000
Keratin 8 tumoral 51 (100) 0 0.000
Keratin 8 in nest/invasion 51 (100) 0 0.000
E-cadherin intratumoral 51 (100) 0 0.000
E-Cadherin-in invasión 51 (100) 0 0.000
IFI-16 intratumoral 29 (57) 36 (73) 0.063
IFI-16 invasion 51 (100) 0 0.000
HIF1α tumoral 29 (57) 36 (73) 0.063
HIF1α intratumoral 51 (100) 0 0.000

Tubulin intratumoral

 

10 (20)

 

10 (20)

 

0.559

cc0.010
Tubulin invasión 51 (100) 0 0.000

D2DR intratumoral

 

10 (20)

 

10 (20)

 

0.559

cc0.010

D2DR invasión

 

10 (20)

 

10 (20)

 

0.559

cc.010
NGF intratumoral 51 (100) 0 0.000

NGF invasión

 

10 (20)

 

10 (20)

 

0.559

cc0.010
Neurofilaments intratumoral 51 (100) 0 0.000

Neurofilaments invasión

 

10 (20)

 

10 (20)

 

0.559

cc0.010

Vimentin intratumoral

 

10 (20)

 

10 (20)

 

0.559

cc0.010
Vimentin invasión 51 (100) 0 0.000
Nestin intratumoral 20 (20) 10 0.005
Nestin invasión 51 (100) 0 0.000
EVGF intratumoral 51 (100) 0 0.000

EVGF invasión

 

10 (20)

 

10 (20)

 

0.559

cc0.010

cc: Coefficient of correlation of Sperman and Pearson. NGF: Neural grow factor, (D2DR.- Dopamine D2 receptor Interferon- IFI-16 Inducible factor, D5DR Dopamina Receptor 5. IFI-16: Gamma-interferon-inducible protein Ifi-16 (also known as interferon-inducible) myeloid differentiation transcriptional activator, HIF-1α HIF1A; hypoxia inducible factor 1, alpha subunit.