Table 1: The endogenous intoxication (EI) in infants.

The main risk factors of EI

The main factors of intoxication

1. The oxidative stress (ischemia, hypoxia, shock)

1. The accumulation of oxygen free radicals

2. The anoxic damage of the mitochondria

2. The toxic modification of proteins, DNA and RNA

3. The reduction of toxinsí biotransformation in the liver

3. The depletion of antioxidant system

4. The eliminationí reduction of toxins in the kidneys

4. The damages of the lipids cellular membrane by IBS. The increase of lipidsí inflammatory mediators.

5. Drug intoxication

5. Violation of cellular calcium homeostasis

6. Intoxication be metals

6. Reduction of bioenergy (reduction of ATP concentration and increase of lactate)

7. The excessive accumulation of metabolites

7. Fermentopathy

8. Natural and industrial xenobiotics

8. The accumulation of homocysteine and uric acid

9. Genetic abnormalities

9. The accumulation of average molecules

-

10. The activation of proteins of an acute inflammation phase

-

11. Autoimmune reactions

-

12. Recycling of toxicants in kidney

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Abbreviations

DNA: Deoxyribonucleic Acid; RNA: Ribonucleic Acid; ATP: Adenosine Triphosphate Acid