Table 1: Inclusion and exclusion criteria.
| Inclusion criteria | Exclusion criteria |
| Pediatric patients (1 to 18-years-old) | Patients over 18 years |
| 5 kg weight or greater | Patients under 5 Kg |
| Los Angeles grade Cesophagitis valued by endoscopy | Without data of esophagitis |
| Hiatal hernia up to 3 cm | Hiatal hernia up to 3 cm |
| Ph Demeester index score greater than 14° more than 95% of acid symptoms | Ph Demeester index score index greater than 14° less than 95% of acid symptoms |
| Manometry with basal pressure lower than 13 mmHg | Manometry with basal pressure higher than 13 mmHg |
| Accepted by the Bioethics Committee | Not accepted by the Bioethics Committee |
| Inform consent form duly completed and signed | Without inform consent form duly completed and signed |