Table 2: Baseline neonatal characteristics by dose-delivery interval (n = 659).

Neonatal characteristics

DDI category 1

< 155 mins

(n = 166)

DDI category 2

155-314 mins

(n = 164)

DDI category 3

314-526.5 mins

(n = 165)

DDI category 4

> 526.5 mins

(n = 164)

P-value

Gender

 

 

 

 

0.814

Male

82 (49.4%)

79 (48.8%)

77 (47.0%)

73 (44.5%)

 

Female

84 (50.6%)

83 (51.2%)

87 (53.0%)

91 (55.5%)

 

Gestational age (weeks), median (IQR)

38.86 (38-40)

39.29 (38.14-40.21)

39.29 (38.43-40.14)

39.71 (38.71-40.29)

0.001

Birthweight (grams), mean +/- SD

3289.22 +/- 500.71

3307.08 +/- 510.77

3358.20 +/- 475.59

3434.51 +/- 468.78

0.034

Apgar 1-minute, median (IQR)

9 (9-9)

9 (8-9)

9 (8-9)

9 (9-9)

0.023

Apgar 1-minute, binary

 

 

 

 

0.082

Less than 7

12 (7.2%)

25 (15.2%)

16 (9.7%)

14 (8.5%)

 

More than 7

154 (92.8%)

139 (84.8%)

149 (90.3%)

150 (91.5%)

 

Apgar 5 minute, median (IQR)

9 (9-9)

9 (9-9)

9 (9-9)

9 (9-9)

0.591

Apgar 5-minute, binary

 

 

 

 

0.04

Less than 7

1 (0.6%)

7 (4.3%)

1 (0.6%)

2 (1.2%)

 

More than 7

165 (99.4%)

157 (95.7%)

164 (99.4%)

162 (98.8%)

 

Neonatal resuscitation

 

 

 

 

0.014

No

60 (36.1%)

36 (22.2%)

56 (33.9%)

61 (37.2%)

 

Yes

106 (63.9%)

126 (76.8%)

108 (65.5%)

103 (62.8%)

 

Tactile                              stimulation

 

 

 

 

0.018

(resuscitation)

 

 

 

 

 

No

61 (36.7%)

39 (24.1%)

58 (35.4%)

65 (39.6%)

 

Yes

105 (63.3%)

123 (75.9%)

106 (64.6%)

99 (60.4%)

 

Continuous     positive                          airway

 

 

 

 

0.047

pressure (CPAP) (resuscitation)

 

 

 

 

 

No

152 (91.6%)

134 (82.7%)

148 (90.2%)

148 (90.2%)

 

Yes

14 (8.4%)

28 (17.3%)

16 (9.8%)

16 (9.8%)

 

Intermittent positive pressure ventilation           (IPPV)

(resuscitation)

 

 

 

 

0.001

No

155 (93.4%)

135 (83.3%)

152 (92.7%)

156 (95.1%)

 

Yes

11 (6.6%)

27 (16.7%)

12 (7.3%)

8 (4.9%)

 

Oxygen therapy (resuscitation)

 

 

 

 

0.151

No

166 (100.0%)

160 (98.8%)

163 (99.4%)

164 (100.0%)

 

Yes

0 (0.0%)

2 (1.2%)

1 (0.6%)

0 (0.0)

 

Dextrose (resuscitation)

 

 

 

 

0.253

No

166 (100.0%)

161 (99.4%)

164 (100.0%)

164 (100.0%)

 

Yes

0 (0.0%)

1 (0.6%)

0 (0.0)

0 (0.0)

 

Volume expander (resuscitation)

 

 

 

 

0.483

No

166 (100.0%)

161 (99.4%)

163 (99.4%)

164 (100.0%)

 

Yes

0 (0.0%)

1 (0.6%)

1 (0.6%)

0 (0.0)

 

External cardiac massage and ventilation (resuscitation)

 

 

 

 

0.496

No

166 (100.0%)

161 (99.4%)

163 (99.4%)

164 (100.0%)

 

Yes

0 (0.0%)

1 (0.6%)

1 (0.6%)

0 (0.0)

 

Neonatal characteristics

DDI category 1

< 155 mins

(n = 166)

DDI category 2

155-314 mins

(n = 164)

DDI category 3

314-526.5 mins

(n = 165)

DDI category 4

> 526.5 mins

(n = 164)

P-value

Transfer to tertiary care centre

 

 

 

 

0.781

No

165 (99.4%)

162 (98.8%)

162 (98.2%)

162 (98.8%)

 

Yes

1 (0.6%)

2 (1.2%)

3 (1.8%)

2 (1.2%)

 

Admission to special care nursery

 

 

 

 

0.972

No

130 (78.3%)

129 (78.7%)

130 (78.8%)

125 (76.2%)

 

Yes

36 (21.7%)

35 (21.3%)

35 (21.2%)

39 (23.8%)

 

Respiratory          issues (SCN admission)

 

 

 

 

0.508

No

32 (88.9%)

30 (14.3%)

30 (85.7%)

30 (76.9%)

 

Yes

4 (11.1%)

5 (14.3%)

5 (14.3%)

9 (23.1%)

 

Feeding difficulties

 

 

 

 

0.786

No

100 (90.1%)

104 (91.2%)

106 (87.6%)

103 (88.0%)

 

Yes

11 (9.9%)

10 (8.8%)

15 (12.4%)

14 (12.0%)