Cohort A

(1998-2008)

Cohort B

(2009-2020)

Over whole period

n/(%), Cohort A vs. B

Number of children

88

138

226

Mean age presentation (± SEM)                   

3.75 ± 0.32

3.88 ± 0.26

NS

E. coli 0157:H7 detected

43

87

130 P = 0.011

Other bacteria identified

Campylobacter jejuni

Cryptosporidium

Aeromonas species

Viruses (Adenovirus)

-

1

-

-

3

-

1

1

Mean prodrome duration (days)   

6.9 ± 0.4              

5.9 ± 0.2

6.4 p = 0.04

Bloody diarrhoea

58

110

168 (74.3) p 0.028

Seizures

7

24

31 (13.7%) NS

Jaundice

13

21

34 (15) NS

Acute hypertension

31

40

71 (31.4) NS

Anuria  

46

62

108 (47.7) NS

Mean anuria duration (days)

6.3 ± 0.6

5.9 ± 0.6

6.1 NS

Number dialysed

54

74

128 (56.6) NS

Mean duration of dialysis

9.4 ± 0.9

11.0 ± 0.77

10.2 NS