A) BMI biometrical descriptive statistic from 1990 to 2015 including number of patient data sets, average BMI, median BMI, SD (standard deviation) BMI, maximum BMI, minimum BMI, BMI range, 1st quartile BMI and 3rd quartile BMI.

Table 1: A) BMI biometrical descriptive statistic from 1990 to 2015 including number of patient data sets, average BMI, median BMI, SD (standard deviation) BMI, maximum BMI, minimum BMI, BMI range, 1^st quartile BMI and 3^rd quartile BMI.

Year	Number of Patient data		BMI average		BMI median
	Frankfurt	Moscow	Frankfurt	Moscow	Frankfurt	Moscow
1990	2	0	21.52	-	21.52	-
1991	2	1	21.54	14.49	21.54	14.49
1992	1	2	21.50	16.27	21.50	16.27
1993	2	7	20.91	16.44	20.91	15.08
1994	1	11	20.02	17.34	20.02	17.16
1995	10	7	16.66	17.36	16.11	17.16
1996	30	10	18.84	16.91	18.52	17.39
1997	35	23	19.41	17.61	19.55	17.72
1998	46	38	19.89	16.34	19.66	16.45
1999	45	39	19.97	17.33	19.13	17.65
2000	30	45	20.29	16.98	19.09	16.53
2001	14	53	19.07	16.79	18.05	16.85
2002	16	64	18.78	17.41	18.02	17.54
2003	68	78	21.43	17.42	20.85	17.55
2004	75	103	21.48	17.49	20.76	17.57
2005	13	101	20.57	18.04	20.68	18.03
2006	13	124	20.95	18.02	21.27	17.96
2007	13	160	20.51	18.11	21.10	18.13
2008	91	179	21.69	18.38	21.01	18.55
2009	84	188	22.39	18.55	21.81	18.52
2010	132	192	21.20	18.76	20.70	18.69
2011	137	199	21.40	18.71	21.14	18.47
2012	131	250	21.80	18.79	21.62	18.51
2013	130	263	21.99	18.68	21.66	18.29
2014	133	278	22.12	18.78	21.73	18.52
2015	141	301	22.24	18.74	21.63	18.59
Year	BMI standard deviation (SD)		BMI maximum		BMI minimum
	Frankfurt	Moscow	Frankfurt	Moscow	Frankfurt	Moscow
1990	0.64	-	21.98	-	21.07	-
1991	1.13	-	22.34	14.49	20.75	14.49
1992	-	1.75	21.50	17.51	21.50	15.03
1993	1.26	2.88	21.80	20.93	20.02	13.22
1994	-	3.82	20.02	25.00	20.02	13.34
1995	2.29	2.37	20.64	22.21	13.68	15.43
1996	3.17	2.21	25.83	19.37	14.07	13.47
1997	3.18	2.49	28.22	22.77	13.71	13.34
1998	3.18	3.58	27.64	22.77	13.65	1.92
1999	3.52	2.51	31.11	22.94	14.88	12.63
2000	4.89	2.71	37.56	24.15	13.13	12.70
2001 2002	4.02	2.69	27.76	22.76	14.60	12.40
2001 2002	2.94	2.65	24.01	23.23	14.74	11.65
2003	3.76	2.70	33.30	23.61	13.98	11.65
2004	4.05	2.77	35.50	24.88	12.93	10.82
2005	3.22	2.76	26.35	25.86	13.73	12.02
2006	3.35	2.83	26.67	25.72	14.38	12.03
2007	3.58	2.73	24.97	25.62	13.89	12.73
2008	4.10	2.79	40.75	26.23	14.38	11.83
2009	4.41	2.78	44.29	26.03	15.34	12.80
2010	4.20	2.84	45.35	30.03	14.27	12.60
2011	4.18	2.90	45.52	31.99	14.35	12.47
2012	4.03	2.69	45.34	27.73	13.86	12.47
2013	4.04	2.80	44.47	27.73	13.86	10.85
2014	4.17	2.86	45.41	31.46	14.10	13.02
2015	4.13	2.78	46.60	31.46	14.17	11.33
Year	BMI range		BMI 1^st quartile		BMI 3^rd quartile
	Frankfurt	Moscow	Frankfurt	Moscow	Frankfurt	Moscow
1990	0.91	-	-	-	-	-
1991	1.59	0.00	-	-	-	-
1992	0.00	2.48	-	-	-	-
1993	1.78	7.71	-	14.49	-	18.42
1994	0.00	11.66	-	14.22	-	19.30
1995	6.96	6.78	15.21	15.64	17.29	17.70
1996	11.76	5.90	16.51	15.35	20.88	18.85
1997	14.51	9.43	17.38	15.89	20.87	19.12
1998	13.99	20.85	17.93	14.22	21.60	18.46
1999	16.23	10.32	17.79	15.41	21.72	19.00
2000	24.43	11.45	17.59	14.81	21.15	19.23
2001	13.16	10.36	15.90	14.66	21.14	18.67
2002	9.27	11.58	16.76	15.23	21.38	18.93
2003	19.33	11.96	19.03	15.23	22.92	19.11
2004	22.57	14.06	19.23	15.21	23.00	19.47
2005	12.61	13.85	19.33	16.37	22.01	19.68
2006	12.29	13.69	19.76	15.66	22.60	19.82
2007	11.08	12.89	20.48	16.28	22.92	19.91
2008	26.37	14.40	19.58	16.47	22.80	20.09
2009	28.95	13.22	20.03	16.71	23.46	19.93
2010	31.08	17.43	18.81	16.97	22.95	20.20
2011	31.17	19.53	19.05	16.93	23.13	20.45
2012	31.48	15.27	19.34	16.86	23.29	20.45
2013	30.61	16.88	19.58	16.82	23.69	20.43
2014	31.32	18.44	19.31	16.86	23.81	20.50
2015	32.43	20.13	19.31	16.82	24.14	20.32

B) FEV1 biometrical descriptive statistic from 1990 to 2015 including number of patient data, average FEV1, median FEV1, SD (standard deviation) FEV1, maximum FEV1, minimum FEV1, FEV1 range, 1st quartile FEV1 and 3rd quartile FEV1.

Year	Number of Patient data		FEV1 average		FEV1 median
	Frankfurt	Moscow	Frankfurt	Moscow	Frankfurt	Moscow
1990	2	0	3800	-	3800	-
1991	2	0	3590	-	3590	-
1992	1	1	4370	2820	4370	2820
1993	2	4	3600	1280	3600	1000
1994	1	8	2550	1706.25	2550	1210
1995	6	6	2136.67	1216.67	2030	1155
1996	27	6	1825.93	1783.33	1800	1685
1997	34	19	2150.88	1998.42	2070	1640
1998	42	24	2357.62	1783.33	2090	1350
1999	44	28	2244.32	2215.00	2205	1980
2000	28	25	2512.86	2193.20	2555	2300
2001	13	30	2333.85	2019.67	2120	1955
2002	17	37	2328.82	2026.76	2090	1920
2003	66	50	2439.39	2186.00	2320	2000
2004	71	67	2447.89	2221.34	2340	2020
2005	15	73	2366.67	2296.71	2350	2030
2006	13	87	2571.54	2202.41	2450	2040
2007	13	125	2728.46	2301.36	2480	2130
2008	93	155	2354.73	2247.81	2230	2010
2009	86	171	2488.72	2299.30	2450	2220
2010	133	169	2463.91	2270.77	2270	2120
2011	137	176	2446.93	2192.33	2300	2090
2012	133	234	2437.44	2136.54	2230	2030
2013	135	251	2450.67	2120.84	2370	2020
2014	135	275	2426.81	2057.35	2310	1900
2015	145	295	2460.34	1983.12	2290	1850
Year	FEV1 standard deviation (SD)		FEV1 maximum		FEV1 minimum
	Frankfurt	Moscow	Frankfurt	Moscow	Frankfurt	Moscow
1990	565.69	-	4200	-	3400	-
1991	1343.50	-	4540	-	2640	-
1992	-	-	4370	2820	4370	2820
1993	1173.80	671.71	4430	2280	2770	840
1994	-	1290.10	2550	4390	2550	610
1995	638.55	647.79	3320	2420	1520	600
1996	512.72	1070.49	3090	3180	920	630
1997	726.81	1160.03	3960	4060	870	610
1998	883.31	1036.85	4400	3820	1090	570
1999	821.57	1126.85	4310	5020	130	580
2000	906.30	948.37	4080	3810	900	870
2001	1041.78	1000.76	4330	4330	560	570
2002	1053.90	905.15	4540	4060	600	660
2003	1027.37	1044.13	5820	4510	500	600
2004	908.67	1063.67	4870	4790	570	480
2005	1074.40	1141.05	4530	6490	920	460
2006	930.45	1036.96	4530	5980	960	610
2007	1053.31	1043.37	4590	5650	1340	510
2008	971.57	1114.60	5030	5870	580	380
2009	1055.56	1073.32	5440	6240	560	480
2010	1036.99	981.22	5390	5390	710	730
2011	1028.96	1036.40	5440	5080	650	420
2012	1023.65	1036.54	5130	6420	580	450
2013	1015.53	1034.53	5300	6400	690	500
2014	1042.62	990.51	5370	5130	730	192
2015	1112.38	985.01	5410	5220	600	520
Year	FEV1 range		FEV1 1^st quartile		FEV1 3^rd quartile
	Frankfurt	Moscow	Frankfurt	Moscow	Frankfurt	Moscow
1990	800	-	-	-	-	-
1991	1900	-	-	-	-	-
1992	0	0	-	2820	-	2820
1993	1660	1440	-	930	-	1350
1994	0	3780	-	870	-	1972.5
1995	1800	1820	1755	807.5	2200	1247.5
1996	2170	2550	1515	892.5	2060	2590
1997	3090	3450	1720	1090	2517.5	2975
1998	3310	3250	1772.5	975	2897.5	2472.5
1999	4180	4440	1775	1357.5	2607.5	3085
2000	3180	2940	1760	1230	3402.5	2740
2001	3770	3760	1520	1135	3000	2655
2002	3940	3400	1600	1280	3090	2540
2003	5320	3910	1755	1262.5	3157.5	2807.5
2004	4300	4310	1805	1405	2915	2865
2005	3610	6030	1805	1540	2790	2710
2006	3570	5370	2030	1500	2870	2695
2007	3250	5140	1920	1680	3440	2840
2008	4450	5490	1670	1370	2940	2985
2009	4880	5760	1732.5	1455	2980	3045
2010	4680	4660	1690	1560	2980	2970
2011	4790	4660	1680	1355	2960	2890
2012	4550	5970	1670	1332.5	3060	2820
2013	4610	5900	1690	1315	2975	2730
2014	4640	4938	1690	1230	2895	2785
2015	4810	4700	1600	1245	3280	2585

C) Biometrical descriptive statistical analysis of necessity of intravenous antibiotic therapy from 1990 to 2015 including number of patient data, number of necessity of intravenous antibiotic therapy and percentage of necessity of intravenous antibiotic therapy.

Year	Number of Patient data		Necessity of intravenous antibiotic therapy
	Frankfurt	Moscow	Frankfurt		Moscow
1990	24	1	1		0
1991	24	2	1		0
1992	25	3	1		1
1993	26	9	1		2
1994	26	15	1		3
1995	27	12	3		4
1996	27	15	2		4
1997	27	26	2		8
1998	30	43	6		15
1999	31	44	6		18
2000	33	54	7		20
2001	36	61	10		19
2002	41	83	21		26
2003	48	90	25		31
2004	58	111	32		44
2005	63	118	27		46
2006	66	147	24		64
2007	69	180	32		79
2008	90	209	43		99
2009	98	201	35		97
2010	118	209	47		100
2011	130	222	49		105
2012	130	256	48		130
2013	139	270	52		143
2014	142	274	57		167
2015	148	295	58		191
Year	Percentage of necessity of intravenous antibiotic therapy
	Frankfurt			Moscow
1990	4.17			0.00
1991	4.17			0.00
1992	4.00			33.33
1993	3.85			22.22
1994	3.85			20.00
1995	11.11			33.33
1996	7.41			26.67
1997	7.41			30.77
1998	20.00			34.88
1999	19.35			40.91
2000	21.21			37.04
2001	27.78			31.15
2002	51.22			31.33
2003	52.08			34.44
2004	55.17			39.64
2005	42.86			38.98
2006	36.36			43.54
2007	46.38			43.89
2008	47.78			47.37
2009	35.71			48.26
2010	39.83			47.85
2011	37.69			47.30
2012	36.92			50.78
2013	37.41			52.96
2014	40.14			60.95
2015	39.19			64.75