Table 2: Sex-stratified prevalence and adjusted* odds ratio (OR) of morbidities for adults with spinal muscular atrophy (SMA) and matched adults without SMA (w/o SMA).
|
SMA |
w/o SMA |
SMA vs. w/o SMA |
||
Female |
Male |
Female |
Male |
Females and males combined |
|
|
% (n) |
% (n) |
% (n) |
% (n) |
OR (95% CI) |
Hypertension |
61.8 (735) |
64.9 (803) |
46.2 (109,756) |
48 (118,579) |
2.45 (2.22, 2.70) |
Chronic pulmonary disease |
35.0 (416) |
29.5 (365) |
13.3 (31,541) |
11.2 (27,616) |
3.63 (3.32, 3.97) |
Bone fragility |
34.0 (405) |
17.1 (211) |
13.7 (32,474) |
4.2 (10,403) |
4.10 (3.71, 4.54) |
Osteoarthritis |
33.4 (398) |
25.7 (318) |
16.3 (38,686) |
10.9 (26,928) |
2.97 (2.70, 3.26) |
Anemia |
32.2 (383) |
29.1 (360) |
11.3 (26,921) |
8.3 (20,580) |
4.63 (4.22, 5.09) |
Cardiac arrhythmias |
31.6 (376) |
33.1 (410) |
13.3 (31,691) |
14.2 (35,082) |
3.38 (3.09, 3.71) |
Fluid/electrolyte disorders |
30.5 (363) |
29.6 (366) |
7.0 (16,599) |
5.1 (12,714) |
7.80 (7.10, 8.57) |
Diabetes |
25.3 (301) |
30.9 (382) |
16.6 (39,525) |
20.2 (49,880) |
1.79 (1.63, 1.97) |
Hypothyroidism |
25.0 (298) |
11.6 (144) |
18.3 (43,507) |
6.8 (16,765) |
1.61 (1.45, 1.80) |
Gastrointestinal issues |
24.1 (287) |
20.0 (247) |
6.3 (14,917) |
3.7 (9,084) |
5.69 (5.15, 6.28) |
Cerebrovascular disease |
22.9 (272) |
20.9 (258) |
6.5 (15,425) |
6.7 (16,442) |
4.59 (4.13, 5.11) |
Anxiety |
22.3 (265) |
17.0 (210) |
9.5 (22,666) |
4.7 (11,552) |
3.26 (2.95, 3.61) |
Sleep disorders (excludes sleep-related hypoventilation) |
22.3 (265) |
22.6 (280) |
7.6 (18,137) |
9.5 (23,464) |
3.11 (2.82, 3.42) |
Pneumonia |
19.6 (233) |
21.1 (261) |
3.4 (8,069) |
3.4 (8,418) |
8.00 (7.20, 8.89) |
Congestive heart failure |
17.8 (212) |
15.8 (195) |
5.0 (11,906) |
5.5 (13,475) |
4.18 (3.71, 4.70) |
Psychoses |
16.7 (199) |
14.8 (183) |
5.9 (14,041) |
3.4 (8,478) |
3.87 (3.46, 4.32) |
Cancer |
14.7 (175) |
19.7 (244) |
10.4 (24,711) |
12.7 (31,451) |
1.63 (1.46, 1.82) |
Depression |
14.7 (175) |
10.3 (127) |
3.7 (8,798) |
1.8 (4,400) |
5.15 (4.56, 5.83) |
Renal disease |
14.3 (170) |
16.6 (205) |
6.3 (14,915) |
7.0 (17,355) |
2.77 (2.45, 3.12) |
Urine incontinence |
11.3 (135) |
9.7 (120) |
2.7 (6,418) |
1.3 (3,177) |
6.13 (5.35, 7.03) |
Dementia |
11.2 (133) |
9.5 (118) |
3.7 (8,760) |
1.9 (4,741) |
5.11 (4.36, 5.99) |
Liver disease |
6.5 (77) |
5.6 (69) |
2.1 (4,975) |
2.3 (5,760) |
2.82 (2.38, 3.34) |
Myocardial infarction |
5.6 (67) |
8.3 (103) |
1.9 (4,438) |
3.6 (8,785) |
2.72 (2.32, 3.20) |
Migraine |
5.4 (64) |
1.0 (12) |
2.5 (5,873) |
0.7 (1,627) |
2.08 (1.65, 2.63) |
Neurogenic bladder or bowel |
5.2 (62) |
6.4 (79) |
0.2 (507) |
0.3 (764) |
23.6 (19.3, 28.3) |
Rheumatoid arthritis and other inflammatory polyarthropathies |
5.1 (61) |
2.2 (27) |
2.2 (5,162) |
1.0 (2,497) |
2.34 (1.89, 2.90) |
Epilepsy |
5.0 (60) |
5.5 (68) |
0.9 (2,140) |
0.9 (2,115) |
6.28 (5.24, 7.52) |
Alcohol or drug abuse |
4.0 (48) |
4.4 (55) |
1.0 (2,350) |
1.8 (4,401) |
3.15 (2.58, 3.84) |
Intellectual disabilities |
1.8 (22) |
1.9 (23) |
0.1 (155) |
0.1 (224) |
24.3 (17.8, 33.2) |
Sleep-related hypoventilation |
1.0 (12) |
< 1%** |
0.1 (127) |
0.1 (161) |
11.8 (7.2, 19.2) |
CI: Confidence interval; *Adjusted for age (continuous) and sex; **Data suppressed as N ≤ 11 for patient de-identification purposes.