Table 3: Odds ratio (OR) of morbidities with effect modification by sex, comparing adults with spinal muscular atrophy (n = 2,427) to matched adults without spinal muscular atrophy (n = 484,528).
|
Females |
Males |
|
OR (95% CI) |
OR (95% CI) |
Congestive heart failure |
4.81 (4.07, 5.69) |
3.66 (3.09, 4.32) |
Cerebrovascular disease |
5.04 (4.33, 5.87) |
4.20 (3.62, 4.89) |
Bone fragility |
3.65 (3.20, 4.15) |
4.91 (4.21, 5.74) |
Dementia |
3.94 (3.17, 4.91) |
6.94 (5.54, 8.70) |
Depression |
4.49 (3.82, 5.28) |
6.32 (5.25, 7.61) |
Anxiety |
2.72 (2.37, 3.12) |
4.17 (3.59, 4.84) |
Psychoses |
3.20 (2.74, 3.73) |
4.88 (4.17, 5.72) |
Alcohol or drug abuse |
4.22 (3.15, 5.64) |
2.57 (1.96, 3.37) |
Sleep disorders (excludes sleep-related hypoventilation) |
3.49 (3.04, 4.01) |
2.80 (2.45, 3.20) |
Sleep-related hypoventilation |
18.9 (10.4, 34.2) |
* |
Fluid/electrolyte disorders |
6.84 (5.97, 7.82) |
8.89 (7.80, 10.1) |
Gastrointestinal issues |
4.94 (4.30, 5.66) |
6.72 (5.83, 7.76) |
Urine incontinence |
4.78 (3.96, 5.77) |
8.55 (7.02, 10.4) |
CI: Confidence Interval; *Too few outcome events to provide a meaningful estimate.