Table 3: Odds ratio (OR) of morbidities with effect modification by sex, comparing adults with spinal muscular atrophy (n = 2,427) to matched adults without spinal muscular atrophy (n = 484,528).

 

Females

Males

 

OR (95% CI)

OR (95% CI)

Congestive heart failure

4.81 (4.07, 5.69)

3.66 (3.09, 4.32)

Cerebrovascular disease

5.04 (4.33, 5.87)

4.20 (3.62, 4.89)

Bone fragility

3.65 (3.20, 4.15)

4.91 (4.21, 5.74)

Dementia

3.94 (3.17, 4.91)

6.94 (5.54, 8.70)

Depression

4.49 (3.82, 5.28)

6.32 (5.25, 7.61)

Anxiety

2.72 (2.37, 3.12)

4.17 (3.59, 4.84)

Psychoses

3.20 (2.74, 3.73)

4.88 (4.17, 5.72)

Alcohol or drug abuse

4.22 (3.15, 5.64)

2.57 (1.96, 3.37)

Sleep disorders (excludes sleep-related hypoventilation)

3.49 (3.04, 4.01)

2.80 (2.45, 3.20)

Sleep-related hypoventilation

18.9 (10.4, 34.2)

*

Fluid/electrolyte disorders

6.84 (5.97, 7.82)

8.89 (7.80, 10.1)

Gastrointestinal issues

4.94 (4.30, 5.66)

6.72 (5.83, 7.76)

Urine incontinence

4.78 (3.96, 5.77)

8.55 (7.02, 10.4)

CI: Confidence Interval; *Too few outcome events to provide a meaningful estimate.