Table 4: Comparison between the levels of studied inflammatory biomarkers on admission and after 72 hours according to the outcome on the 14th day$.

Biomarkers

Stages

Outcome on the 14th day

p value

Non-survivors

(8; 24.2%)

Survivors (25; 75.8%)

On room air

(14; 43%)

On O2 therapy or CPAP (11; 33%)

IL-6

(pg/ml)

Admission

376 .0

(26.3-511)

9.8

(0.1-39.4)

6.8

(0.3-14.2)

x2 =  4.846

P = 0.089

72 hours

1.6

(0.1-187.6)

0.1

(0.1-0.3)

7.2

(0.1-41.3)

x2 = 7.003

p = 0.03*

IL-8

(pg/ml)

Admission

29.2

(9.1-164.5)

14.4

(10.4-26.1)

16.8

(9.6-28.9)

x2 = 0.447

p = 0.799

72 hours

13.9

(4.8-23.6)

12.7

(7.9-24.8)

28.2

(13.0-55.6)

x2 = 3.125

p = 0.2

CRP (mg/L)

Admission

2.4

(2.5-3.3)

2.4

(2.0-3.4)

3.0

(1.9-3.5)

x2 = 0.844

p = 0.656

72 hours

1.8

(0.7-2.3)

1.4

(0.2-2.2)

2.5

(2.0-2.8)

x2 = 4.687

p = 0.096

 

IL-6: interleukin-6, IL-8: interleukin-8, CRP: C-reactive protein, O2: oxygen, CPAP: continuous positive airway pressure, x2: Kruskal Wallis test, $ all data are presented in median and interquartile range (IQR), *significant at p ≤ 0.05.