Table1: HDACIs and their involvements in myocardial infarction.

 

HDACIs

Targets

Function

Signaling pathway Reference

VPA

Increase t-PA release

Improve endogenous fibrinolytic capacity; reduced risk for myocardial infarction

t-PA; PAI-1 [35,37]

CPA

Inhibit HDAC2

Prevent neointima formation, adipocytic differentiation, lipid accumulation

PPAR-r [38,39]

SAHA

Inhibit HDAC1,2

Reduce infarct size; promote autophagy

Autophagic; [45,47] anti-inflammatory

TSA

Inhibit HDAC1,2

Stimulates myogenesis and angiogenesis; reduce infarct size

Chop; p38MAPK [41,42]

Scipataid

Mocetinostat

Synthetic HDACI

Inhibit HDAC 1,2,3

Reduce infarct size

 

Reverse HDACs activity [48,49]

IL-6/STST3 axis [35,50]