Generation of iNSCs by various neuronal-specific transcription factors from somatic cells.

Table 1: Generation of iNSCs by various neuronal-specific transcription factors from somatic cells.

Ref.	Reprogramming factors	Self-renew	Differentiated cell types			Cell origin
Ref.	Reprogramming factors	Self-renew	neurons	astrocytes	oligodendrocytes	Cell origin
[101]	Sox2, Klf4, c-Myc, Oct4	+	+	+	n/a*	MEFs
[88]	Sox2, Brn2, FoxG1	+	+	+	+	MEFs
[87]	Sox2, Klf4, c-Myc, Oct4	+	+	+	+	MEFs
[99]	Sox2, Klf4, c-Myc, Brn4 with/without E47	+	+	+	+	MEFs
[120]	Sox2, Klf4, c-Myc, Brn4	+	+	+	+	MEFs
[123]	Sox2, Klf4, c-Myc, Brn2, Pax6, Id1, Hex1, Ngn2, Ascl1	+	+	+	+	Mouse Sertoli cells
[121]	Sox2	+	+	+	+	MEFs/HFFs
[122]	Sox2 or Oct4 or Nanog	+	+	+	+	Human astrocytes
* n/a, not available; Abbreviations: MEFs, mouse embryo fibroblasts; HFFs, human foreskin fibroblasts