Table 3: Mobilization of NSCs in neurogenesis of the adult brain

Strategies for NSCs activation

Niches of NSCs activation

Expected improvement of CNS injuries

Learning

HVC (SVZ)

Developmental verbal dyspraxia;

Mental retardation syndrome Fragile X

Exercise

Hippocampus

Major psychiatric disorders (depression, schizophrenia, drug addiction);

Cerebral infarction;

Aging-related cognitive decline

Stroke

SVZ

Stroke

Muse

Mesenchymal tissue

Cell-based therapy

Magnetism

SVZ/ hippocampus

Neuropsychiatric disorders (major psychiatric disorders, schizophrenia, epilepsy, neuropathic pain, amyotrophic lateral sclerosis, progressive muscle atrophy, multiple sclerosis);

Neurodegenerative diseases (Alzheimer’s disease, Parkinson's disease, Huntington’s disease);

Stroke

Ultrasound

Hippocampus

Major depression disorder;

Alzheimer’s disease

Abbreviations: Muse, multilineage-differentiating stress-enduing cells; HVC, high vocal center; SVZ, subventricular zone